Dataset Information

Modulation of Serpin family levels detected by proteomics to monitor colorectal adenoma to carcinoma progression

ABSTRACT: Colorectal cancer (CRC) remains a major cause of cancer related-death in developed countries. The risk of death is correlated with the stage of CRC determined at the primary diagnosis and early diagnosis is associated with enhanced survival rate. Consequently, there is an interest in using proteomics technologies to identify specific markers of adenomatous polyps as well as advanced stages of CRC.This study supports the concept that serum proteins can discriminate adenoma and CRC patients from unaffected patients and highlights the value of the SERPIN family as potential biomarkers of CRC.

INSTRUMENT(S): LTQ Orbitrap, 4800 Proteomics Analyzer

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Serum

DISEASE(S): Colon Cancer

SUBMITTER: Luc Camoin

LAB HEAD: Luc Camoin

PROVIDER: PXD001794 | Pride | 2016-08-26

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	F10__iTRAQ_LTQ_Velos.mgf	Mgf
	F10_iTRAQ_LTQ_Velos.raw	Raw
	F10_iTRAQ_LTQ_Velos_run2.mgf	Mgf
	F10_iTRAQ_LTQ_Velos_run2.raw	Raw
	F11_iTRAQ_LTQ_Velos.mgf	Mgf

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Publications

Quantitative proteomic analysis exploring progression of colorectal cancer: Modulation of the serpin family.

Peltier Julien J Roperch Jean-Pierre JP Audebert Stéphane S Borg Jean-Paul JP Camoin Luc L

Journal of proteomics 20160802

<h4>Unlabelled</h4>Colorectal cancer (CRC) remains a major cause of cancer related-death in developed countries. The mortality risk is correlated with the stage of CRC determined at the primary diagnosis and early diagnosis is associated with enhanced survival rate. Currently, only faecal occult blood tests are used to screen for CRC. Consequently, there is an incentive to identify specific markers of CRC. We used quantitative proteomic analysis of serum samples to characterize protein profiles ...[more]

PMID: 27492143

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