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NHLBI TOPMed: Diabetes Heart Study (DHS) African American Coronary Artery Calcification (AA CAC)

ABSTRACT:

The Diabetes Heart Study (DHS) is a family-based study enriched for type 2 diabetes (T2D). The cohort included 1443 European American and African American participants from 564 families with multiple cases of type 2 diabetes (Bowden et al., 2010. Review of Diabetic Studies 7:188-201. PMID: 21409311). The cohort was recruited between 1998 and 2006. Participants were extensively phenotyped for measures of subclinical CVD and other known CVD risk factors. Primary outcomes were quantified burden of vascular calcified plaque in the coronary artery, carotid artery, and abdominal aorta all determined from non-contrast computed tomography scans.

PROVIDER: phs001412 | dbGaP |

SECONDARY ACCESSION(S): PRJNA394787PRJNA394788

REPOSITORIES: dbGaP

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			Action	DRS
	GapExchange_phs001412.v1.p1.xml	Xml
	dbGaPEx2.1.5.xsd	Other
	phs001412.v1-Documents.zip	Other
	Study_Report.phs001412.TOPMed_WGS_DHS_AA_CAC.v1.p1.MULTI.pdf	Pdf
	manifest_phs001412.TOPMed_WGS_DHS_AA_CAC.v1.p1.c1.HMB-IRB-COL-NPU.pdf	Pdf

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The Diabetes Heart Study (DHS)

Project description:<p>The Diabetes Heart Study is a family based study enriched for type 2 diabetes (T2D). The cohort included 1220 self-reported European Americans from 475 families (Bowden et al 2010 Review of Diabetic Studies 7:188-201: <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=21409311">PMID: 21409311</a>; Bowden et al 2008 Annals of Human Genetics 72:598-601 <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=18460048">PMID: 18460048</a>) and included siblings concordant for T2D; where possible unaffected siblings were also recruited. The cohort was recruited between 1998 and 2006. Participants were extensively phenotyped for measures of subclinical CVD and other known CVD risk factors. Primary outcomes were quantified burden of vascular calcified plaque in the coronary artery, carotid artery and abdominal aorta all determined from non-contrast computed tomography scans. </p>

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