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Genomic Regions Associated with Susceptibility to Barrett's Esophagus and Esophageal Adenocarcinoma in African Americans: The Cross BETRNet Admixture Study

ABSTRACT:

Differences in rates of diseases between different populations with similar environments are presumed to be secondary to variability in population frequencies of disease causing alleles. Recently admixed populations such as African Americans (AAs) provide a natural opportunity to identify disease-causing variants by examining the ancestry of long chromosomal haplotypes. Admixture mapping approach can be successful in locating genes for diseases such as EAC whose rates varies markedly between the ancestral populations. This is a case only study with 54 African American cases and also on a subset of 28 cases with high genotyping quality. We seek to identify chromosome regions that have excess European ancestry and contrasting it to excess African ancestry.

PROVIDER: phs001454 | dbGaP |

SECONDARY ACCESSION(S): PRJNA406852PRJNA406853

REPOSITORIES: dbGaP

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			Action	DRS
	GapExchange_phs001454.v1.p1.xml	Xml
	dbGaPEx2.1.5.xsd	Other
	Study_Report.phs001454.CrossBETRNetAdmixture.v1.p1.MULTI.pdf	Pdf
	manifest_phs001454.CrossBETRNetAdmixture.v1.p1.c1.GRU-IRB.pdf	Pdf
	datadict_v2.xsl	Other

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