Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Analysis of the Genetic Basis of Height in Large Jewish Nuclear Families

ABSTRACT:

This is a family based study of the genetic basis of height, which focused on very large nuclear families (10 siblings or more, average of 12), all from a founder (Jewish) population. All participants have completed their growth. This study design increases the frequency of some genetic variants that are rare in a cosmopolitan population but segregate in our cohort. Participants were genotyped with a ~630,000 SNP array (Affymetrix Axiom Biobank), and their standing height, sitting height and arm span were measured with high accuracy (±0.1 cm, with 4 technical repeats). All genomic coordinates refer to genome build hg19.

PROVIDER: phs001852 | dbGaP |

REPOSITORIES: dbGaP

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	GapExchange_phs001852.v1.p1.xml	Xml
	dbGaPEx2.1.5.xsd	Other
	datadict_v2.xsl	Other
	phs001852.v1.pht009275.v1.Height_Jewish_Subject.data_dict.xml	Xml
	phs001852.v1.pht009275.v1.p1.Height_Jewish_Subject.var_report.xml	Xml

Items per page:

1 - 5 of 15

Similar Datasets

myb52-2 t-dna -Transcriptome analysis of atmyb52 mutant vs wild-type

Project description:rs11-11_myb52 - myb52-2 t-dna - What are the structural and regulator genes regulated by MYB52 transcription factor? - Plants grew in short-day growth chamber until they reached 20 cm height. Ten centimeter-stem from the rosette were collected. Samples are pools of 8 wild-type (Col0) or (atmyb52) mutant plants. Two biological repeats were conducted.

2013-02-01 | GSE43647 | GEO

myb52-2 t-dna -Transcriptome analysis of atmyb52 mutant vs wild-type

2013-02-01 | E-GEOD-43647 | biostudies-arrayexpress

A genome scan for genes underlying adult body size differences between Central African hunter-gatherers and farmers.

Project description:The evolutionary and biological bases of the Central African pygmy phenotype, a characteristic of rainforest huntergatherers defined by reduced body size compared with neighboring farmers, remain largely unknown. Here, we perform a joint investigation in Central African hunter-gatherers and farmers of adult standing height, sitting height, leg length, and body mass index (BMI), considering 358 hunter-gatherers and 169 farmers with genotypes for 153,798 SNPs. In addition to reduced standing heights, hunter-gatherers have shorter sitting heights and leg lengths and higher sitting/standing height ratios than farmers and lower BMI for males. Standing height, sitting height, and leg length are strongly correlated with inferred levels of farmer genetic ancestry, whereas BMI is only weakly correlated, perhaps reflecting greater contributions of non-genetic factors to body weight than to height. Single- and multi-marker association tests identify one region and eight genes associated with hunter-gatherer/farmer status, and 24 genes associated with the height-related traits. Many of these genes have putative functions consistent with roles in determining their associated traits and the pygmy phenotype, and they include three associated with standing height in non-Africans (PRKG1, DSCAM, MAGI2). We find evidence that European height-associated SNPs or variants in linkage disequilibrium with them contribute to standing- and sitting-height determination in Central Africans, but not to the differential status of hunter-gatherers and farmers. These findings provide new insights into the biological basis of the pygmy phenotype, and they highlight the potential of cross-population studies for exploring the genetic basis of phenotypes that vary naturally across populations. Pemberton et al. Human Genetics 2018 https://doi.org/10.1007/s00439-018-1902-3

| EGAS00001002975 | EGA

Circularized chromosome conformation capture (4C-seq) in A549 cells after glucocorticoid re-induction

Project description:We performed 4C-seq in the A549 cell line to investigate changes in chromatin interactions at the ZBTB16 locus. Cells were treated with either 100 nM dexamethasone or 0.1% ethanol. After 4 hours, cells were washed 2x with PBS and cultured in hormone-free medium for 24 hours, after which cells were treated again for 4 hours with either 100 nM dexamethasone or 0.1% ethanol. Experiments were performed in two biological replicates. For each treatment, 4C-seq data were generated for the following two viewpoints: ZBTB16 promoter-proximal viewpoint coordinates: chr11:113929670-113930464 (hg19) ZBTB16 intronic viewpoint coordinates: chr11:114051224-114051804 (hg19)

2021-05-03 | E-MTAB-9915 | biostudies-arrayexpress

Analysis of the genetic basis of height in large Jewish nuclear families

Project description:Analysis of the genetic basis of height in large Jewish nuclear families

| PRJNA550150 | ENA

Analysis of the genetic basis of height in large Jewish nuclear families

Project description:Analysis of the genetic basis of height in large Jewish nuclear families

| PRJNA550151 | ENA

CentralAfricanCMC_Pemberton

Project description:The CentralAfricanCMC_Pemberton dataset encompasses 153,798 SNPs from the Illumina Cardio-MetaboChip (Voight et al. 2012) genotyped in 406 individuals from 19 Central African Populations from Gabon, Cameroon, Centralafrican Republic and Uganda). Individual phenotypic and cultural information at the individual level for this data set encompass gender, lifestyle (hunter-gatherer or farmer), and, when available, stature phenotype (standing height in cm, sitting-height in cm, and weight in kg). Other cultural, linguistic, and geographical location information about the sampled populations can be found in Pemberton et al. , Human Genetics, 2018 (https://doi.org/10.1007/s00439-018-1902-3).This dataset can only be accessed and used for non-commercial research purposes with a finality complying with the informed consent provided by Central African donors for the study of human evolutionary history only.

| EGAD00010001584 | EGA

Transcriptome analysis during the growth and development of asparagus stems

Project description:Asparagus is a nutritionally dense stem vegetable whose growth and development are correlated with its quality and yield. For height of 25 cm asparagus , 17-20 cm is still viable, in which the cells can continue to elongate. When 40 cm, the growth in the 17-20 cm range basically stops. Therefore, we picked periods with significant growth differences for transcriptome comparison to find the dynamic changes and underlying mechanisms during the elongation and growth process of asparagus stems. The results showed that the differentially expressed genes were enriched in many aspects, including the metabolism of plant hormones and carbohydrates.

2024-02-29 | GSE252560 | GEO

Small RNAs from third instar Drosophila melanogaster males

Project description:The goal of this study was to determine if small RNAs from the 1.688 g/cm 3 satellite repeats are present in male larvae.

2014-12-02 | GSE61846 | GEO

Identification of genes differentially expressed during the growth of Bambusa oldhamii

Project description:To gain insights into the molecular mechanisms controlling bamboo growth, mRNA differential display was used to clone genes that are differentially expressed in various tissues of shoots at different growth stages, and their expression patterns were further validated by cDNA microarray. A number of genes and signaling pathways are proposed to have significant roles in controlling the elongation of the bamboo culm. Etiolated shoots (average height: 15 cm) that had not yet emerged from the ground and green shoots (average height: 100 cm) of Bambusa oldhamii were collected. The shoots were divided into three parts, the culm base, the middle and the top regions for RNA extraction and processing. The RNA from the middle region of the etiolated shoots was used as a reference in microarray comparisons.

2012-12-31 | E-GEOD-40095 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data