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Intestinal microbiota in colorectalcancer

ABSTRACT: Interventions: An explorative prospective multicenter cohort study in the Maastricht University Medical Centre+, Catharina Hospital and Zuyderland Medical Centre will be performed in 66 patients. Before, during, and after three cycles of systemic treatment with capecitabine or TAS-102, fecal samples and questionnaires (concerning compliance and chemotoxicity) will be collected. The response will be measured by CT/MRI using RECIST-criteria. Fecal microbiota composition will be analyzed with 16S rRNA next-generation sequencing. The absolute bacterial abundance will be assessed with quantitative polymerase chain reaction. Multivariate analysis will be used for statistical analysis. Primary outcome(s): Microbiota composition before, during and after 3 cycles systemic treatment with capecitabine or TAS-102 related to respons & chemotoxicity Study Design: N/A , unknown, Other

DISEASE(S): Intestinal Microbiota, Microbiome, Colorectal Cancer Treatment, Chemotoxicity, Responsintestinale Microbiota, Microbioom, Colorectaal Carcinoom Behandeling, Chemotoxiciteit, Respons

PROVIDER: 20955 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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