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Exercise-acclimated microbiota improves skeletal muscle metabolism

ABSTRACT: Habitual exercise modulates the composition of the intestinal microbiota. We examined whether transplanting fecal microbiota from trained mice improved skeletal muscle metabolism in high-fat diet-fed mice. The recipient mice that received fecal samples from trained donor mice for 1 week showed elevated levels of metabolic signalings in skeletal muscle. Glucose tolerance was improved by fecal microbiota transplantation after 8 weeks of HFD administration. Intestinal microbiota may mediate exercise-induced metabolic improvement in mice. We performed a microarray analysis to compare the metabolic gene expression profiles in the skeletal muscle from each mouse.

ORGANISM(S): Mus musculus

PROVIDER: GSE201202 | GEO | 2022/06/30

REPOSITORIES: GEO

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Exercise-acclimated microbiota improves skeletal muscle metabolism

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