Browse
Submit Data
Databases
API
Help

Dataset Information

5 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Trial Comparing Simple Follow-up to Exploratory Laparotomy Plus "in Principle" (Hyperthermic Intraperitoneal Chemotherapy) HIPEC in Colorectal Patients

ABSTRACT: Multicentric randomised trial. Patients with a high risk of developing colorectal Peritoneal Carcinomatosis (PC) after resection of their primary will be informed, will sign the consent and will be pre-registered. All patients will receive the current standard adjuvant treatment : 6 months of systemic chemotherapy (currently the Folfox-4 regimen which could be modified if the standard is modified). Then a work-up is done to exclude recurrence. The likelihood of a recurrence is low but if this occurs, the patient will not be randomised and will be treated with the best known treatment. If the work-up is negative, patients will be randomised to surveillance alone (control group) or exploratory laparotomy + HIPEC (experimental group).

DISEASE(S): Tumour Rupture In The Abdominal Cavity,Ovarian Metastases,Rupture,Colorectal Cancer With A Resected Minimal Synchronous Pc,Colorectal Cancer,Cancers Colorectaux À Très Haut Risque De Développer Une Carcinose Péritonéale,Peritoneal Carcinomatosis,Krukenberg Tumor

PROVIDER: 2096967 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

RNA-sequencing in skeletal muscle from a mouse model of laparotomy with pre-operative running wheel exercise

Project description:This study aimed to characterize the effects of pre-operative volitional running wheel exercise on post-operative physical function and skeletal muscle gene expression in 24-month-old C57BL/6N mice following laparotomy. Soleus muscles collected on post-operative day 5 (POD 5) were used for this study.

2022-04-28 | GSE201252 | GEO

Colectomy for Cancer in the Elderly by Laparoscopy or Laparotomy

Project description:The purpose of this study is to compare the postoperative global morbidity between patients who have been operated on for a colon cancer by laparotomy and those operated on by laparoscopy

| 2235205 | ecrin-mdr-crc

Gene expression profiling study to identify key markers associated with disease recurrence in colorectal cancers.

Project description:The objective of this study is to identify a gene set to predict recurrence of colorectal cancer (CRC) patients. We generated RNA-seq data of 110 primary CRC samples and identified significant genes associated with recurrence of CRC. Through diverse statistical methods including generalized linear model likelihood ratio test, significant 10 genes were identified. In the validation cohorts, a risk classifier consisting of the 10 genes was an independent risk factor in colorectal cancers.

2019-10-29 | GSE107422 | GEO

RNA-sequencing in skeletal muscle from a mouse model of laparotomy with pre-operative running wheel exercise

Project description:RNA-sequencing in skeletal muscle from a mouse model of laparotomy with pre-operative running wheel exercise

| PRJNA830506 | ENA

Project description:Modified sequencing library prep with less clean-up steps

| PRJNA776692 | ENA

Serum metabolomic profiles identify ER-positive early breast cancer patients at increased risk of disease recurrence in a multicentre population

Project description:PURPOSE: Detecting signals of micrometastatic disease in early breast cancer (EBC) patients could improve risk stratification and allow better tailoring of adjuvant therapies. We have previously shown that postoperative serum metabolomic profiles are predictive of relapse in a single-centre cohort of ERnegative EBC patients. Here, we investigated this further using pre-operative serum samples from ER-positive, premenopausal women with EBC who were enrolled in an international phase III trial. METHODS: Proton nuclear magnetic resonance (NMR) spectroscopy of 590 EBC samples (319 with relapse or =6 years clinical follow up) and 109 metastatic breast cancer (MBC) samples was performed. A Random Forest (RF) classification model was built using a training set of 85 EBC and all MBC samples. The model was then applied to a test set of 234 EBC samples, and a risk of recurrence score was generated based on the likelihood of the sample being misclassified as metastatic. RESULTS: In the training set, the RF model separated EBC from MBC with discrimination accuracy of 84.9%. In the test set, the RF recurrence risk score correlated with relapse, with an area under the curve of 0.747 in receiver operator characteristics analysis. Accuracy was maximised at 71.3% (sensitivity 70.8%, specificity 71.4%). The model performed independently of age, tumor size, grade, HER2 status and nodal status, and also of AdjuvantOnline risk of relapse score.CONCLUSIONS: In a multicentre group of EBC patients, we developed a model based on preoperative serum metabolomic profiles that was prognostic for disease recurrence, independent of traditional clinicopathological risk factors.

2017-03-02 | MTBLS424 | MetaboLights

Affymetrix data for training of Endopredict algorithm

Project description:These data, combined with other cohorts (GSE6532, GSE12093, and qRT-PCR based cohorts), was used to construct the EP algorithm, which predicts the likelihood of developing of a distant recurrence of early stage breast cancer under endocrine treatment. In addition, EPclin, a combination of the EP score, the nodal status and the tumor size, was constructed.

2011-10-11 | GSE26971 | GEO

Liver Transcriptomes of Simple steatosis in Mice

Project description:In our study, we constructed a Simple steatosis (NAFL) mouse model with a high-fructose and high-cholesterol (HFHC diet) for 12 weeks. Next, we performed RNA Sequencing analysis to reveal molecular features of Simple steatosis. As a result, we obtained hepatic genome-wide mRNA expression in the livers from two groups of mice (NAFL versus Normal).Using FDR < 0.01 and fold change > 2 as the threshold, we identified 176 differentially expressed genes (DEGs) in the livers of NAFL mice relative to the normal control mice, of which 118 up-regulated and 58 down-regulated. The top 5 up-regulated genes in NAFL mice included the genes encoding for Themis, Cfd, Aqp8, Osbpi3 and Scd1.

2022-03-25 | GSE199121 | GEO

Evaluation of the inflammatory response to minilaparotomy compared to conventional laparotomy in the surgical resection of colorectal cancer including its influence on long term survival and local recurrence

Project description:Study hypothesis: To compare standard surgical approach to minilaparotomy in patients undergoing surgical resection for colorectal cancer. Once group will have surgery in the conventional manner and the other will have it performed using a mini-laparotomy. A mini-laparotomy being where the incision, through which the abdominal cavity is entered to reach the cancer, is 15cm or less; whereas conventionally a cut is made along the entire length of the abdomen. We aim to show that there is a reduced inflammatory response to the mini-laparotomies by measuring inflammatory markers (cytokines) from blood samples taken before and after surgery. We believe that a reduced acute inflammatory response post surgery has benefits for the patient in both the short term with regards to improved recovery times to mobilisation and restoration of bowel function and the longer term with relation to rates of local recurrence of the tumour and overall prognosis. Primary outcome(s): The primary outcome measure is the amount of acute inflammatory markers (the cytokines IL-6, IL-2, IL-1beta and TNF-alpha) measured from venous blood samples taken 1 day pre operation, day 1, day 5 and 2 months post surgery in the two groups.

| 2424569 | ecrin-mdr-crc

circRNAs, miRNAs and mRNAs expression profiling in rBMSCs affected by Ta-modified Ti surface or simple Ti surface

Project description:We have employed circRNAs, miRNAs and mRNAs expression profiling as a discovery platform to identify genes with the potential to distinguish rBMSCs affected by Ta-modified Ti surface or simple Ti surface

2020-11-18 | GSE161611 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data