Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effects of Eicosapentaenoic Acid on Subjects at High Risk for Colorectal Cancer

ABSTRACT: The aim of this study is to test Eicosapentaenoic acid’s effects on markers relevant to colorectal carcinogenesis, RNA and DNA profiles, and the possibility that Eicosapentaenoic Acid treatment might be associated with changes of the gut microbiota and metabolomic profiles in patients with long-standing ulcerative colitis.

DISEASE(S): Colitis, Ulcerative,Ulcerative Colitis,Colitis

PROVIDER: 2161328 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

Alteration of microbiota antibody-mediated immune selection contributes to dysbiosis in IBD

Project description:The goal of this project is to find out whether human intestinal IgA1 and IgA2 secretion, transport and reactivity towards the microbiota might be involved in dysbiosis induction during Crohn’s disease and Ulcerative colitis. Mass spectrometry was used to characterize SIgA from Crohn’s disease patient and Ulcerative colitis patient, in term of O- and N-glycosylation in order to study their reverse transcytosis capacity and their role in intestinal inflammation.

2022-06-27 | PXD024060 | Pride

Bias in Gene-Set Analysis Applied to High-throughput Methylation Data

Project description:Gene set analysis as it is typically applied to genome-wide methylation assays is severely biased as a result of differences in the numbers and sizes of CpG islands associated with different classes of genes. We demonstrate this bias using published data from a study of differential methylation in lung cancer and a data set we generated to study methylation changes in patients with long-standing ulcerative colitis and show that several of the gene sets that appear enriched would also be identified with randomized data. We also report a method to correct the bias. Application of the corrected method to the lung cancer and ulcerative colitis data sets provides novel and potentially interesting biological insights into the role of methylation in cancer development and chronic inflammation. We used Agilent Human CpG Island microarrays to compare methylation patterns in sigmoid colon tissue between five individuals suffering from ulcerative colitis and five healthy age-matched controls.

2012-07-12 | E-GEOD-39188 | biostudies-arrayexpress

DNA methylation in a discovery cohort of colon mucosa samples from individuals with Crohns' disease or ulcerative colitis and normal controls

Project description:Genome wide DNA methylation profiling of Crohn's disease, ulcerative colitis, and normal colon mucosa samples. The Illumina Infinium HumanMethylation450 BeadChip v1.1 was used to obtain DNA methylation profiles across 482,421 CpGs in colon mucosa samples. Samples came from 10 Crohn's disease affected, 4 ulcerative colitis affected, and 10 normal individuals. One ulcerative colitis sample was assayed before and after treatment with 6-mercaptopurine and mesalamine.

2013-06-01 | GSE32146 | GEO

DNA methylation in a validation cohort of colon mucosa samples from individuals with Crohns' disease or ulcerative colitis and normal controls

Project description:Genome wide DNA methylation profiling of Crohn's disease, ulcerative colitis, and normal colon mucosa samples. The Illumina Infinium HumanMethylation450 BeadChip v1.1 was used to obtain DNA methylation profiles across 482,421 CpGs in colon mucosa samples. Samples came from 5 Crohn's disease affected, 5 ulcerative colitis affected, and 12 normal individuals. One ulcerative colitis sample was assayed before and after treatment with infliximab and mesalamine.

2015-01-01 | GSE42921 | GEO

miRNA data in colon mucosa samples from individuals with ulcerative colitis and normal controls

Project description:Genome wide miRNA profiling of ulcerative colitis, and normal colon mucosa samples. The GeneChip miRNA 3.0 Array was used to obtain miRNA profiles across colon mucosa samples. Samples came from 5 ulcerative colitis affected, and 5 normal individuals.

2015-01-01 | GSE43009 | GEO

DNA methylation in peripheral blood from individuals with Crohns' disease or ulcerative colitis and normal controls

Project description:Genome wide DNA methylation profiling of Crohn's disease, ulcerative colitis, and normal peripheral blood samples. The Illumina Infinium HumanMethylation450 BeadChip v1.1 was used to obtain DNA methylation profiles across 482,421 CpGs in peripheral blood samples. Samples came from 17 Crohn's disease affected, 11 ulcerative colitis affected, and 20 normal individuals. Within these samples were three twin sets discordant for Crohn's disease and three twin sets discordant for ulcerative colitis.

2012-04-05 | GSE32148 | GEO

Expression data in colon mucosa samples from individuals with ulcerative colitis and normal controls

Project description:Genome wide expression profiling of ulcerative colitis, and normal colon mucosa samples. The GeneChip PrimeView Human Gene Expression Array was used to obtain expresion profiles across colon mucosa samples. Samples came from 5 ulcerative colitis affected, and 5 normal individuals.

2015-01-01 | GSE42911 | GEO

DNA methylation in peripheral blood from individuals with Crohns' disease or ulcerative colitis and normal controls

2012-04-04 | E-GEOD-32148 | biostudies-arrayexpress

miRNA expression in human colitis-associated dysplasia

Project description:Patients with ulcerative colitis (UC) are at increased risk of colorectal cancer (CRC). Colitis-associated dysplasia (flat or polypoid) continues to be a reliable marker for CRC in these patients. However, flat lesions are often missed during endoscopy and can rapidly progress to high-grade dysplasia or cancer. microRNAs (miRs), small non-coding RNAs, have emerged as a valuable diagnostic biomarker of human cancer due to their ease of detection and stability. The goal of this study was to identify a miR signature that can serve as a reliable biomarker for the early detection of colitis-associated dysplasia in patients with long-standing colitis.

2022-07-23 | GSE209581 | GEO

miRNA data in colon mucosa samples from individuals with ulcerative colitis and normal controls

2015-01-01 | E-GEOD-43009 | biostudies-arrayexpress