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Erbitux MEtastatic Colorectal Cancer Strategy Study

ABSTRACT: * To investigate whether cetuximab alone (given until progression or cumulative toxicity) after 8 cycles of FOLFIRI + cetuximab results in a non inferior Progression Free Survival when compared with continuous FOLFIRI + cetuximab (given until progression or cumulative toxicity). * To assess whether an improvement in the incidence of grade 3-4 hematological and non-hematological adverse events (AEs) can be achieved in the experimental arm (cetuximab alone after 8 cycles FOLFIRI + cetuximab) as compared to the continuous chemotherapy arm (FOLFIRI plus cetuximab) * To explore the possibility of using liquid biopsies for molecular profiling as well as monitoring treatment activity in mCRC pts receiving cetuximab based therapy

DISEASE(S): Metastatic Colorectal Cancer,Patients With Unresectable Ras And Braf Wild-type Metastatic Colorectal Cancer.,Antineoplastic Agents,Colorectal Neoplasms

PROVIDER: 2193137 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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