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Intermittent or continuous Panitumumab plus FOLFIRI for first-line treatment of patients with RAS/B-RAF wild-type metastatic colorectal cancer: a randomized phase 2 trial

ABSTRACT: Primary objectives: To investigate whether experimental intermittent treatment of Panitumumab + FOLFIRI (given until progression during treatment or cumulative toxicity) results in a Progression Free Survival on treatment (PFSOT) similar to that obtained with standard continuous treatment of Panitumumab + FOLFIRI (given until progression or cumulative toxicity). Primary endpoints: PFSot is defined as the time from randomization to the firstobjective disease progression documented in patients undergoing treatment cycle (objective disease progression during treatment free intervals are excluded) or death due to any cause, whichever occurs first.

DISEASE(S): Colorectal Adenocarcinoma,Pazienti Affetti Da Tumore Del Colon-rettometastatico Ras/braf Wild-type,Patients With Ras/b-raf Wild-type Metastatic Colorectal Cancer

PROVIDER: 2537370 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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