Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

European Novel Motorized Spiral Endoscopy Trial

ABSTRACT: The subject Novel Motorized Spiral Enteroscope (NMSE) represents a new technology which offers all of the advantageous options of spiral enteroscopy with a faster and less invasive approach. The system is similar to other currently marketed endoscopes in that it incorporates a flexible insertion tube, light source, digital imaging, and channels for passing accessories for sample collection or therapeutic interventions. The NMSE system is unique in that it incorporates a user-controlled motor contained in the endoscope’s handle to rotate a spiral cuff located on the endoscope’s insertion tube. Rotation of this cuff, which has soft spiral-shaped "fins", pleats the small bowel on to the endoscope’s insertion tube, thereby allowing rapid and atraumatic access deep into the small bowel. The system also includes a display monitor, a motor control unit, device to display measured motor current and signal torque, and a set of foot pedals. Motorization of the Spiral Enteroscope and limitation of rotation to a short cuff instead of a long overtube promise to accelerate the procedure, to facilitate insertion and to improve maneuvering the instrument in comparison to conventional spiral enteroscopy

DISEASE(S): Coeliac Disease,Gastrointestinal Hemorrhage,Crohn Disease,Hemorrhage,Small Bowel Tumors,Iron Deficiencies,Crohn's Disease,Intestinal Polyposis Syndrome,Intestinal Polyposis,Disorder Of Small Intestine,Celiac Disease,Iron Deficiency Anaemia,Anemia, Iron-deficiency

PROVIDER: 2229945 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

Proteome analysis by simple and stable nanoESI spray system

Project description:We developed InSpIon system capable of stable nanoESI spray. Here, K562 cell digests were measured by DDA-MS and DIA-MS with the typical open nanoESI spray system (Open system) and the spray system inserted spray tip head into ion transfer tube (Insertion-ITT system), and the InSpIon system.

2023-04-05 | PXD039557 | JPOST Repository

Project description:Massively Parallel Domain Insertion Profiling in Ion Channels

| PRJNA766074 | ENA

Project description:Massively Parallel Domain Insertion Profiling in Ion Channels

| PRJNA766040 | ENA

Single cell transcriptome atlases of the developing mouse and human spinal cord [mouse dataset]

Project description:The spinal cord receives input from peripheral sensory neurons and controls motor output by regulating muscle innervating motor neurons. These functions are carried out by neural circuits comprising molecularly and physiologically distinct neuronal subtypes that are generated in a characteristic spatial-temporal arrangement from progenitors in the embryonic neural tube. The systematic mapping of gene expression in mouse embryos has provided insight into the diversity and complexity of cells in the neural tube. For human embryos, however, less information has been available. To address this, we used single cell mRNA sequencing to profile cervical and thoracic regions in four human embryos of Carnegie Stages (CS) CS12, CS14, CS17 and CS19 from Gestational Weeks (W) 4-7. In total we recovered the transcriptomes of 71,219 cells. Analysis of progenitor and neuronal populations from the neural tube, as well as cells of the peripheral nervous system, in dorsal root ganglia adjacent to the neural tube, identified dozens of distinct cell types and facilitated the reconstruction of the differentiation pathways of specific neuronal subtypes. Comparison with existing mouse datasets revealed the overall similarity of mouse and human neural tube development while highlighting specific features that differed between species. These data provide a catalogue of gene expression and cell type identity in the developing neural tube that will support future studies of sensory and motor control systems.

2021-04-12 | GSE171891 | GEO

Single cell transcriptome atlases of the developing mouse and human spinal cord [human dataset]

2021-04-12 | GSE171890 | GEO

Project description:Chimalacatepec Lava Tube System microbiome

| PRJNA509937 | ENA

Transcriptomic analysis of tendon progenitors of Drosophila leg

Project description:The progenitors of Drosophila leg tendon are specified among leg disc epithelium during third larval instar. At the end of larval stages and beiginning of pupae formation, tendon cells invaginate and then collectively migrate to form a tube-shaped structure.

2021-07-01 | GSE169313 | GEO

Therapeutic strategy for spinal muscular atrophy by combining gene supplementation and genome editing

Project description:Defect in the SMN1 gene causes spinal muscular atrophy (SMA), which shows loss of motor nerve cells, muscle weakness and atrophy. While current treatment strategies including small molecules or viral vectors improved motor function and survival, an ultimate treatment is highly challenging to correct the endogenous mutations by genome-editing technologies. We have developed the CRISPR-Cas9 based homology-independent targeted integration (HITI) strategy, which allowed for DNA knock-in in both dividing and non-dividing cells in vivo. Here, we demonstrated a gene correction of mutant mSmn1 by using the HITI strategy to treat SMA model mice. To provide the long-term therapeutic benefits of gene correction, we established a unique approach to treat SMA by combination with gene cDNA supplementation and editing (Gene-DUET). As a proof of concept of therapeutic approach for SMA, we demonstrated the advantageous effects including motor function and survival improvement by Gene-DUET strategy in SMA model mice. The Gene-DUET represents a powerful strategy for treating inherited diseases especially for neurodegenerative disorders as well as neuromuscular diseases.

2024-06-17 | GSE207181 | GEO

Gene expression analysis of human fallopian tube stem cells and air-liquid interface differentiation

Project description:If the fallopian tube is the origin of serous cancer, one possible mechanism for the evolution of cancer is a dysregulation of indigenous stem cells. We therefore set out to clone the stem cells of the human fallopian tube using methods to clone columnar epithelial stem cells such as human intestinal stem cells. Using this method, we were able to generate clones of fallopian tube stem cells that contain many small, undifferentiated cells. These stem cell clones show strong and consistent staining with markers of fallopian tube epithelial cells (PAX8). We also established an air-liquid interface culture system to differentiate fallopian tube stem cell to both ciliated cells and non-ciliated cells.

2015-09-29 | GSE69453 | GEO

An expansion of genomic regulatory complexity underlies vertebrate neuronal diversity

Project description:The proper assembly and function of the mammalian nervous system requires the generation of a uniquely diverse population of neurons. Neuronal identity can be viewed as a cell-type-specific combination of broadly expressed effector genes (e.g. receptors, cytoskeletal proteins, adhesion molecules, ion channels, neurotransmitters) that collectively define neuronal morphology, connectivity, and function. How countless, partially overlapping, yet cell-type-specific patterns of gene expression are controlled at the genomic level remains poorly understood. Using primary and stem cell-derived motor neurons, we mapped enhancer-promoter interactions, revealing that motor neuron enhancers are distributed across large chromatin domains, instead of clustered as super-enhancers previously described in other tissues. The distributed enhancers converge on promoters to regulate both neuronal cell-type- and cell-stage-specific patterns of gene expression. Distributed dynamic enhancers are not a unique property of motor neurons, but are broadly employed in the regulation of gene expression throughout the nervous system. Together, our findings establish that neuronal genes are associated with expanded non-coding genomic domains, accommodating large numbers of independent cell-type- and cell-stage-specific regulatory elements. This regulatory system facilitates the implementation of complex gene expression programs underlying the expansion in the cellular diversity of the vertebrate central nervous system.

2021-11-03 | GSE149971 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data