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A Dose Escalation and Cohort Expansion Study of NKTR-214 in Combination With Nivolumab and Other Anti-Cancer Therapies in Patients With Select Advanced Solid Tumors


ABSTRACT: In this four-part study, NKTR-214 was administered in combination with nivolumab and with/without other anticancer therapies. Part 1 considered escalating doublet (NKTR 214 + nivolumab) doses to determine the RP2D. Part 2 considered dose expansion cohorts for the doublet (NKTR 214 + nivolumab ± chemotherapy). Part 3 was schedule-finding for a triplet therapy (NKTR 214 + nivolumab + ipilimumab). Part 4 dose expansion for the triplet (NKTR 214 + nivolumab + ipilimumab) was planned to further assess the efficacy of the RP2D triplet combination at dosing schedules from Part 3.

DISEASE(S): Locally Advanced Or Metastatic Solid Tumor Malignancies,Carcinoma,Carcinoma, Transitional Cell,Triple Negative Breast Neoplasms,Melanoma,Colorectal Cancer,Non Small Cell Lung Cancer,Urothelial Carcinoma,Triple Negative Breast Cancer,Hr+/her2- Breast Cancer,Breast Neoplasms,Gastric Cancer,Carcinoma, Renal Cell,Carcinoma, Non-small-cell Lung,Malignant Solid Tumour,Stomach Neoplasms,Renal Cell Carcinoma

PROVIDER: 2231315 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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