Clinical

Dataset Information

0

A Dose Escalation and Cohort Expansion Study of NKTR-214 in Combination With Nivolumab and Other Anti-Cancer Therapies in Patients With Select Advanced Solid Tumors


ABSTRACT: In this four-part study, NKTR-214 was administered in combination with nivolumab and with/without other anticancer therapies. Part 1 considered escalating doublet (NKTR 214 + nivolumab) doses to determine the RP2D. Part 2 considered dose expansion cohorts for the doublet (NKTR 214 + nivolumab ± chemotherapy). Part 3 was schedule-finding for a triplet therapy (NKTR 214 + nivolumab + ipilimumab). Part 4 dose expansion for the triplet (NKTR 214 + nivolumab + ipilimumab) was planned to further assess the efficacy of the RP2D triplet combination at dosing schedules from Part 3.

DISEASE(S): Locally Advanced Or Metastatic Solid Tumor Malignancies,Carcinoma,Carcinoma, Transitional Cell,Triple Negative Breast Neoplasms,Melanoma,Colorectal Cancer,Non Small Cell Lung Cancer,Urothelial Carcinoma,Triple Negative Breast Cancer,Hr+/her2- Breast Cancer,Breast Neoplasms,Gastric Cancer,Carcinoma, Renal Cell,Carcinoma, Non-small-cell Lung,Malignant Solid Tumour,Stomach Neoplasms,Renal Cell Carcinoma

PROVIDER: 2231315 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

Similar Datasets

| 2399809 | ecrin-mdr-crc
2022-01-01 | E-MTAB-4030 | biostudies-arrayexpress
2024-10-24 | GSE268364 | GEO
2024-01-09 | GSE234136 | GEO
| 2266061 | ecrin-mdr-crc
| PRJNA819147 | ENA
| PRJNA819148 | ENA
2024-01-01 | GSE202361 | GEO
| PRJNA665109 | ENA
| 2356733 | ecrin-mdr-crc