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Study of XL092 in Combination With Immuno-Oncology Agents in Subjects With Solid Tumors

ABSTRACT: This is a multicenter Phase 1b, open label, dose-escalation and cohort-expansion study, evaluating the safety, tolerability, PK, preliminary antitumor activity, and effect of biomarkers of XL092 administered alone, and in combination with nivolumab (doublet), nivolumab + ipilimumab (triplet) and nivolumab + relatlimab (triplet) in subjects with advanced solid tumors. In the Expansion Stage, the safety and efficacy of XL092 as monotherapy and in combination therapy will be further evaluated in tumor-specific Expansion Cohorts.

DISEASE(S): Squamous Cell Carcinoma Of Head And Neck,Solid Tumor,Carcinoma,Metastatic Castration-resistant Prostate Cancer,Colorectal Cancer,Non-small Cell Lung Cancer,Carcinoma, Renal Cell,Urothelial Carcinoma,Renal Cell Carcinoma,Head And Neck Squamous Cell Carcinoma,Hepatocellular Carcinoma

PROVIDER: 2399809 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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