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M7824 in Patients With Metastatic Colorectal Cancer or With Advanced Solid Tumors With Microsatellite Instability

ABSTRACT: This phase Ib/II trial studies how well anti-PD-L1/TGFbetaRII fusion protein M7824 (M7824) works in treating patients with colorectal cancer (or with other solid tumors with microsatellite instability) that has spread to other places in the body or cannot be removed by surgery. Immunotherapy with monoclonal antibodies, such as M7824, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.

DISEASE(S): Adenocarcinoma,Stage Ivb Rectal Cancer Ajcc V8,Microsatellite Instability,Metastatic Malignant Solid Neoplasm,Stage Iv Rectal Cancer Ajcc V8,Colorectal Cancer,High-frequency Microsatellite Instability,Rectal Adenocarcinoma,Stage Ivb Colon Cancer Ajcc V8,Rectal Neoplasms,Stage Iva Rectal Cancer Ajcc V8,Stage Iv Colon Cancer Ajcc V8,Colon Cancer,Colon Adenocarcinoma,Stage Iva Colon Cancer Ajcc V8,Colorectal Neoplasms,Refractory Colorectal Carcinoma,Colonic Neoplasms

PROVIDER: 2266132 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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