The CLiFF Study: Change in Liver Function and Fat in Pre-operative Chemotherapy for Colorectal Liver Metastases
Ontology highlight
ABSTRACT:
DISEASE(S): Obesity,Neoplasm Metastasis,Liver Metastasis Colon Cancer,Chemotherapy Effect,Colorectal Cancer,Colorectal Neoplasms,Liver Neoplasms
PROVIDER: 2275775 | ecrin-mdr-crc |
REPOSITORIES: ECRIN MDR
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Project description:Background & Aims
The presence of liver fat with or without inflammation is an independent risk factor for disease and death mortality and morbidity) following the removal (resection) of colorectal liver metastases (bowel cancer tumours that have spread to the liver). High levels of fat in the liver can be linked with obesity (being very overweight) and insulin resistance or it may be caused through neoadjuvant chemotherapy (chemotherapy before surgery). Dietary programmes ( interventions) have been proposed for patients that are not receiving chemotherapy and have an excess of liver fat, but it is not known if similar interventions would be benefit patients with chemotherapy induced fatty changes (fatty changes caused by chemotherapy) . This is because it is not known to what extent this naturally resolves after chemotherapy has been completed in the conventional 4-6 week period between chemotherapy and surgery (washout period). This study looks to investigate changes in liver fat levels within this washout period after chemotherapy.
Who can participate?
Anybody over the age of 18 years old who has or will receive chemotherapy before surgery to remove colorectal liver metastases.
What does the study involve?
Each participant is asked to attend Royal Blackburn Hospital on 2 occasions. The first visit takes place around the time that the participant completes their course of chemotherapy. During this first visit a blood sample is taken to assess liver function, circulating blood fat levels and sugar level control. An indocyanine green clearance test is performed which is a newer more sensitive test of liver function than older blood tests. The participant also has a short chemical shift magnetic resonance scan. On the second visit, 4-5 weeks later, these investigations are performed again.
What are the possible benefits?
There are no perceived benefits to participants. Travel expenses will be reimbursed to alleviate any financial burden.
When is the study starting?
October 2015 to August 2017
Who is funding the study?
Rosemere Cancer Foundation (UK)
Where is the study running?
East Lancashire Hospitals NHS Trust, Blackburn (UK)
Who is the main contact?
1. Mr Daren Subar (scientific) daren.subar@elht.nhs.uk
2. Ms Linda Gregson (public) linda.gregson@elht.nhs.uk
| 2410467 | ecrin-mdr-crc
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