Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Permanent Cell Line Cell
DISEASE(S): Colorectal Cancer
SUBMITTER: Brandon Gassaway
LAB HEAD: Steven Gygi
PROVIDER: PXD019495 | Pride | 2020-12-16
REPOSITORIES: Pride
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Cell 20201209 7
Obesity is a major cancer risk factor, but how differences in systemic metabolism change the tumor microenvironment (TME) and impact anti-tumor immunity is not understood. Here, we demonstrate that high-fat diet (HFD)-induced obesity impairs CD8<sup>+</sup> T cell function in the murine TME, accelerating tumor growth. We generate a single-cell resolution atlas of cellular metabolism in the TME, detailing how it changes with diet-induced obesity. We find that tumor and CD8<sup>+</sup> T cells dis ...[more]