Clinical

Dataset Information

0

Avelumab Combined With Cetuximab and Irinotecan for Treatment Refractory Metastatic Colorectal Microsatellite Stable Cancer


ABSTRACT: Cancer immunotherapy with immunostimulatory antibodies targeting the CTLA-4 or PD-1/PD-L1 pathways has demonstrated its efficacy in variable proportions of cancer. For metastatic colorectal cancer (mCRC) it appeared that only the small subgroup of patients with MSI-H tumors (microsatellite instability-high phenotype) had a clinically meaningful response to the anti-PD-1- L1 antibodies. In the majority group of non-MSI-H CRC (90-95% of patients), current research expect that additional means would be able to render the tumor "immunogenic" (like MSI-H CRC) and increase the intratumoral immune infiltrate which is the prerequisite to observe a benefit from PD1-PD-L1 inhibitors. Combinations of immune checkpoint inhibitors and procedures that increase intratumoral immune responses, such as targeted therapy, are actively explored.

DISEASE(S): Colorectal Neoplasms, Malignant,Treatment For Refractory Metastatic Microsatellite Stable Colorectal Cancer,Colorectal Neoplasms,Neoplasms

PROVIDER: 2279295 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

Similar Datasets

2024-03-21 | PXD041000 | JPOST Repository
| phs001464 | dbGaP
2023-02-28 | GSE220909 | GEO
2016-10-17 | GSE81698 | GEO
2018-06-12 | GSE115594 | GEO
2018-07-26 | GSE114300 | GEO
2023-07-06 | PXD039710 | Pride
2021-07-13 | PXD027167 | Pride
2020-04-16 | E-MTAB-7777 | biostudies-arrayexpress
2021-08-19 | GSE177900 | GEO