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Study of Safety and Efficacy of DKY709 Alone or in Combination With PDR001 in Patients With Advanced Solid Tumors.

ABSTRACT: This is a phase I/Ib, open label study. The escalation portion will characterize the safety and tolerability of DKY709 and DKY709 in combination with PDR001 in subjects with NSCLC or melanoma who have received prior anti-PD-1/PD-L1 therapy, or subjects with NPC. After the determination of the MTD/RD for a particular treatment arm, dose expansion will further assess safety, tolerability, PK/PD, and anti-tumor activity of each regimen at the MTD/RD.

DISEASE(S): Nasopharyngeal Carcinoma,Carcinoma,Advanced Or Metastatic Nsclc, Melanoma, Npc, Msscrc, Or Tnbc,Triple Negative Breast Neoplasms,Microsatellite Stable Colorectal Cancer,Melanoma,Non-small Cell Lung Cancer,Colorectal Neoplasms,Carcinoma, Non-small-cell Lung,Triple Negative Breast Cancer

PROVIDER: 2301104 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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PD-L1 ChIP-seq in MDA-MB-231 cells

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Anti-PD-L1 antibody direct activation of macrophages contributes to an abscopal response in murine brain tumors

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DRG2 is required for cell surface localization of PD-L1 in melanoma cells and optimum response to anti-PD-1 immune checkpoint blockade [scRNA-seq]

2023-11-06 | GSE231973 | GEO

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