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Immune Checkpoints in Colorectal Cancer

ABSTRACT: Colorectal cancer (CRC) ranked the first in cancer incidence in Hong Kong and it is frequently lethal with heterogeneous drug responses and survival outcomes. Immune-based approaches targeting to enhance tumor-specific responses have been actively under investigation as therapeutic strategies. Currently, PD1 and PD-L1 blockade has shown promising results in clinical trials especially in colorectal cancer patients with microsatellite instability. This study aims to examine the role of PD-L1/PD1 in immune cell-mediated cytotoxicity in colorectal cancer patients.

DISEASE(S): Colorectal Cancer,Colorectal Neoplasms

PROVIDER: 2313349 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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