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Dasatinib for the Prevention of Oxaliplatin-Induced Neuropathy in Patients With Metastatic Gastrointestinal Cancer Receiving FOLFOX Chemotherapy With or Without Bevacizumab

ABSTRACT: This phase Ib trial studies side effects and best dose of dasatinib in preventing oxaliplatin-induced peripheral neuropathy in patients with gastrointestinal cancers who are receiving FOLFOX regimen with or without bevacizumab. Drugs used in chemotherapy, such as leucovorin, fluorouracil, and oxaliplatin (FOLFOX regimen), work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. However, the buildup of oxaliplatin in the cranial nerves can result in damage or the nerves. Dasatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Blocking these enzymes may reduce oxaliplatin-induced peripheral neuropathy.

DISEASE(S): Stage Ivc Colorectal Cancer Ajcc V8,Stage Iva Colorectal Cancer Ajcc V8,Stage Iii Colon Cancer,Stage Iv Colorectal Cancer Ajcc V8,Carcinoma,Gastrointestinal Neoplasms,Metastatic Colorectal Carcinoma,Advanced Colorectal Carcinoma,Pancreatic Cancer,Stage Ii Rectal Cancer,Stage Ivb Colorectal Cancer Ajcc V8,Stage Ii Colon Cancer,Small Bowel Adenocarcinoma,Stage Iii Rectal Cancer,Rectal Neoplasms,Bile Duct Neoplasms,Gallbladder Neoplasms,Gastric Cancer,Esophageal Cancer,Bile Duct Cancer,Colorectal Neoplasms,Gall Bladder Cancer,Colonic Neoplasms

PROVIDER: 2322001 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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