Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors

ABSTRACT: This phase II trial studies the effect of avapritinib in treating malignant solid tumors that have a genetic change (mutation) in CKIT or PDGFRA and have spread to nearby tissue or lymph nodes (locally advanced) or other places in the body (metastatic). Avapritinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Avapritinib may help to control the growth of malignant solid tumors.

DISEASE(S): Adenocarcinoma,Stage Iva Colorectal Cancer Ajcc V8,Metastatic Malignant Solid Neoplasm,Stage Iiic Lung Cancer Ajcc V8,Locally Advanced Primary Malignant Central Nervous System Neoplasm,Postneoadjuvant Therapy Stage Ivb Gastroesophageal Junction Adenocarcinoma Ajcc V8,Central Nervous System Neoplasms,Anatomic Stage Iv Breast Cancer Ajcc V8,Metastatic Melanoma,Breast Neoplasms,Lung Neoplasms,Stage Iiic Colorectal Cancer Ajcc V8,Neoplasms,Locally Advanced Melanoma,Stage Ivb Colorectal Cancer Ajcc V8,Pathologic Stage Ivb Gastroesophageal Junction Adenocarcinoma Ajcc V8,Clinical Stage Iv Gastroesophageal Junction Adenocarcinoma Ajcc V8,Metastatic Primary Malignant Central Nervous System Neoplasm,Esophageal Neoplasms,Metastatic Sarcoma,Colorectal Neoplasms,Nervous System Neoplasms,Prognostic Stage Iiic Breast Cancer Ajcc V8,Postneoadjuvant Therapy Stage Iv Gastroesophageal Junction Adenocarcinoma Ajcc V8,Prognostic Stage Iv Breast Cancer Ajcc V8,Stage Ivc Colorectal Cancer Ajcc V8,Stage Iv Colorectal Cancer Ajcc V8,Sarcoma,Clinical Stage Ivb Gastroesophageal Junction Adenocarcinoma Ajcc V8,Melanoma,Stage Iva Lung Cancer Ajcc V8,Pathologic Stage Iva Gastroesophageal Junction Adenocarcinoma Ajcc V8,Stage Ivb Lung Cancer Ajcc V8,Postneoadjuvant Therapy Stage Iva Gastroesophageal Junction Adenocarcinoma Ajcc V8,Locally Advanced Sarcoma,Locally Advanced Malignant Solid Neoplasm,Pathologic Stage Iv Gastroesophageal Junction Adenocarcinoma Ajcc V8,Stage Iv Lung Cancer Ajcc V8,Clinical Stage Iva Gastroesophageal Junction Adenocarcinoma Ajcc V8

PROVIDER: 2368674 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR