Browse
Submit Data
Databases
API
Help

Dataset Information

45 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Evaluation of Nexpowder Application to Prevent Delayed Bleeding After Colorectal Endoscopic Mucosal Resection

ABSTRACT: Delayed bleeding is the most frequent (5 to 15%) and challenging complication after large colorectal polypectomy. Different preventive treatments, such as the prophylactic use of clips, have been tried to prevent the occurrence of delayed bleeding, but to date, no treatment has clearly shown its effectiveness. In addition, preventive hemostasis with clips is difficult and costly. A newly developed endoscopic hemostatic powder generating gelation effect (Nexpowder) may be an effective alternative to prevent post polypectomy bleeding in patients treated by endoscopic mucosal resection (EMR) for large superficial colorectal lesions.

DISEASE(S): Colorectal Cancer,Colorectal Neoplasms

PROVIDER: 2405271 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

The Efficacy and Safety of a Hybrid Hemostatic Device (ClearCoajet)

Project description:The ClearCoajet is a new hemostasis device with a hybrid function (Coagulation + Injection) and is developed to provide effective coagulation, injection, and marking around lesions without changing devices during the endoscopic procedure. In this study, the investigators examine the hemostatic effect of ClearCoajet on intraprocedural bleeding during endoscopic mucosal resection or endoscopic submucosal dissection for colorectal sessile polyps or lateral growth tumors larger than 1.5 cm. The investigators also aim to compare the delayed bleeding and recurrence rates between the ClearCoajet group and the control group.

| 9027 | ecrin-mdr-crc

DNA hydrogel based Wound Hemostatic Adjuvant

Project description:Severe traumatic bleeding may lead to extremely high mortality rates, and early intervention to stop bleeding plays as a critical role in saving lives. However, rapid hemostasis in deep non-compressible trauma using a highly water-absorbent hydrogel, combined with strong tissue adhesion and bionic procoagulant mechanism, remains a challenge. In this study, a DNA hydrogel (DNAgel) network composed of natural nucleic acids with rapid water absorption, high swelling and instant tissue adhesion is reported, like a “band-aid” to physically stop bleeding. The excellent swelling behavior and robust mechanical performance, meanwhile, enable the DNAgel band-aid to fill the defect cavity and exert pressure on the bleeding vessels, thereby achieving “compression hemostasis” for deep tissue bleeding sites. The DNAgel network also acts as an artificial DNA scaffold for erythrocytes to adhere and aggregate, and activates platelets, promoting coagulation cascade in a bionic way. The DNAgel achieves lower blood loss than commercial gelatin sponge (GS) in rat trauma models. In vivo evaluation in a full-thickness skin incision model also demonstrated the ability of DNAgel for promoting wound healing. Overall, the DNAgel band-aid with great hemostatic capacity is a promising candidate for rapid hemostasis and wound healing.

2024-07-01 | GSE268849 | GEO

The investigation of prophylactic clip hemorrhage control for colorectal cold snare polypectomy in patients taking anti-thrombotic drugs.

Project description:Interventions: Patients who meet the inclusion criteria and do not meet the exclusion criteria are randomly assigned 1:1 to the clip closure group or the non-clip closure group. Hematochezia will be evaluated in a patient diary for 2 weeks after the cold snare polypectomy.;D016430;CSP clip Antithrombotics Primary outcome(s): Percentage of delayed bleeding within 2 weeks after CSP (per patient). Delayed bleeding is defined as hematochezia requiring endoscopic hemostasis within 2 weeks after CSP. Study Design: randomized controlled trial, open(masking not used), no treatment control/standard of care control, parallel assignment, treatment purpose

| 97511 | ecrin-mdr-crc

Evaluation of usefulness of prophylactically hemostatic clipping for artificial ulcers after cold snare polypectomy for colonic polyps

Project description:Interventions: Cold snare polypectomy Hemostatic clipping after cold snare polypectomy Primary outcome(s): Bleeding rate after cold snare polypectomy. Study Design: Parallel Randomized

| 2633840 | ecrin-mdr-crc

Clinical efficacy of prophylactic clipping of mucosal defects after endoscopic removal for large colorectal neoplasms

Project description:Interventions: Medical Device : After endoscopic removal of colon polyps larger than 2 cm, the mucosal defect is closured with a clips Primary outcome(s): Complication ( delayed bleeding, delayed perforation, post electrocoagulation syndrome );Complication associated clipping ( hemorrhage, perforation) Primary Purpose : Prevention, Intervention Model : Parallel, Blinding/Masking : Single, Blinding Target : Subject, Allocation : RCT

| 2727741 | ecrin-mdr-crc

Investigation for shortening of the time required , easiness and psychological stress for hemostasis using new endoscopic imaging technology (Dual Red Imaging)

Project description:Interventions: 30 cases Period:From August 1 2012 until March 19 2014 DRI or WLI was used alternately in between each bleeding occasion until complete hemostasis was achieved. 3 endpoints were assessed for each bleeding occasion. Primary outcome(s): 1.The average time required for hemostasis by hemostatic forceps in DRI is shorter than that in WLI. 2.The easiness of hemostasis is better in DRI than in WLI. 3. The psychological stress for hemostasis in DRI is lower than that in WLI. Study Design: Single arm Non-randomized

| 2633654 | ecrin-mdr-crc

Anchored Kaolin Scales on Cotton: Towards Rapid and Safe Hemostasis

Project description:we fabricate a bioinspired hemostatic dressing (AKOC) with robust interfacial integration of kaolin and cotton through a potentially scalable self-assembly strategy for efficient and safe hemostasis.

2024-08-22 | GSE275055 | GEO

An Endoscopic Barbed-clips Suturing for Colorectal ESD

Project description:Endoscopic submucosal dissection (ESD) was developed to allow en bloc resection of colorectal neoplasm. Although colorectal ESD has been widely accepted as a minimally invasive treatment option for early colorectal neoplasm, post-ESD bleeding is one of the major adverse events. After ESD procedure, endoscopists close the defects with devices to prevent complications. A novel endoscopic barbed-clips suturing has been developed to simplify endoscopic closure. In this study, the endoscopic barbed-clips will be evaluated when closing defects in the colon after ESD.

| 2389765 | ecrin-mdr-crc

Safety of Endoscopic Resection of Large Colorectal Polyps: A Randomized Trial.

Project description:The effectiveness of colonoscopy in reducing colorectal cancer mortality relies on the detection and removal of neoplastic polyps. Because the risk of prevalent cancer and of transition to cancer increases with polyp size, effective and safe resection of large polyps is particularly important. Large polyps ≥20mm are removed by so-called endoscopic mucosal resection (EMR) using electrocautery snares. Resection of these large polyps is associated with a risk of severe complications that may require hospitalization and additional interventions. The most common risk is delayed bleeding which is observed in approximately 2-9% of patients. A recent retrospective study suggests that closure of the large mucosal defect after resection may decrease the risk of delayed bleeding. However, significant uncertainty remains about the polypectomy techniques to optimizing resection and minimizing risk. Important aspects that may affect risk include clipping of the mucosal defect and electrocautery setting.

| 2151180 | ecrin-mdr-crc

The Risk of Bleeding After Removal of Large Colorectal Polyps in Patients Taking Aspirin

Project description:The risk of bleeding after polypectomy of large colorectal polyps in patients taking aspirin is uncertain. This is a randomized, multi-center, placebo-controlled, double-blind study to compare the risk of significant bleeding after endoscopic polypectomy of large (>=10mm) colorectal polyps in patients continuing or discontinuing on daily acetylsalicylic acid (ASA) use. Eligible patients will be randomly assigned in a 1:1 ratio to a group taking 75mg daily ASA or placebo 7 days before and 14 days following polypectomy. The primary endpoint of the study is bleeding within 30 days from colorectal polypectomy. The secondary endpoints are composite cardiovascular events occurring between the date of randomization and 30 days after polypectomy.

| 2121606 | ecrin-mdr-crc

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data