Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Investigation for shortening of the time required , easiness and psychological stress for hemostasis using new endoscopic imaging technology (Dual Red Imaging)

ABSTRACT: Interventions: 30 cases Period:From August 1 2012 until March 19 2014 DRI or WLI was used alternately in between each bleeding occasion until complete hemostasis was achieved. 3 endpoints were assessed for each bleeding occasion. Primary outcome(s): 1.The average time required for hemostasis by hemostatic forceps in DRI is shorter than that in WLI. 2.The easiness of hemostasis is better in DRI than in WLI. 3. The psychological stress for hemostasis in DRI is lower than that in WLI. Study Design: Single arm Non-randomized

DISEASE(S): Esophageal Cancer, Esophageal Intraepithelial Neoplasia,gastric Cancer, Gastric Adenoma, Colorectal Cancer, Colorectal Adenoma, Barrett’s Esophageal Cancer

PROVIDER: 2633654 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

Multicenter Randomized Controlled Trial for the usefulness of Dual Red Imaging in endoscopic submucosal dissection

Project description:Interventions: The endoscopist commenced the ESD using WLI, switched to DRI immediately when bleeding was detected, then switched back to WLI upon obtaining hemostasis (DRI group). The endoscopist underwent ESD using WLI throughout the entire intervention. Primary outcome(s): Shortening the time required for hemostasis. Study Design: Parallel Randomized

| 2640374 | ecrin-mdr-crc

DNA hydrogel based Wound Hemostatic Adjuvant

Project description:Severe traumatic bleeding may lead to extremely high mortality rates, and early intervention to stop bleeding plays as a critical role in saving lives. However, rapid hemostasis in deep non-compressible trauma using a highly water-absorbent hydrogel, combined with strong tissue adhesion and bionic procoagulant mechanism, remains a challenge. In this study, a DNA hydrogel (DNAgel) network composed of natural nucleic acids with rapid water absorption, high swelling and instant tissue adhesion is reported, like a “band-aid” to physically stop bleeding. The excellent swelling behavior and robust mechanical performance, meanwhile, enable the DNAgel band-aid to fill the defect cavity and exert pressure on the bleeding vessels, thereby achieving “compression hemostasis” for deep tissue bleeding sites. The DNAgel network also acts as an artificial DNA scaffold for erythrocytes to adhere and aggregate, and activates platelets, promoting coagulation cascade in a bionic way. The DNAgel achieves lower blood loss than commercial gelatin sponge (GS) in rat trauma models. In vivo evaluation in a full-thickness skin incision model also demonstrated the ability of DNAgel for promoting wound healing. Overall, the DNAgel band-aid with great hemostatic capacity is a promising candidate for rapid hemostasis and wound healing.

2024-07-01 | GSE268849 | GEO

Anchored Kaolin Scales on Cotton: Towards Rapid and Safe Hemostasis

Project description:we fabricate a bioinspired hemostatic dressing (AKOC) with robust interfacial integration of kaolin and cotton through a potentially scalable self-assembly strategy for efficient and safe hemostasis.

2024-08-22 | GSE275055 | GEO

Evaluation of Nexpowder Application to Prevent Delayed Bleeding After Colorectal Endoscopic Mucosal Resection

Project description:Delayed bleeding is the most frequent (5 to 15%) and challenging complication after large colorectal polypectomy. Different preventive treatments, such as the prophylactic use of clips, have been tried to prevent the occurrence of delayed bleeding, but to date, no treatment has clearly shown its effectiveness. In addition, preventive hemostasis with clips is difficult and costly. A newly developed endoscopic hemostatic powder generating gelation effect (Nexpowder) may be an effective alternative to prevent post polypectomy bleeding in patients treated by endoscopic mucosal resection (EMR) for large superficial colorectal lesions.

| 2405271 | ecrin-mdr-crc

Investigation for gastrointestinal mucosa and submucosa using new endoscopic imaging technology (Dual Red Imaging)

Project description:Interventions: Diagnosis 80 cases, ESD 120 cases Period:From March 20 2014 until April 30 2016 We perform diagnosis or ESD of each case using DRI. Primary outcome(s): 1.Improvement of diagnosis precision: Detection for lesion, Diagnosis of depth of cancer invasion, Assessment for the severity of inflammation. 2.Improvement for visualization of thick blood vessel and bleeding point during ESD. Shortening of total ESD procedure time. Study Design: Single arm Non-randomized

| 2633612 | ecrin-mdr-crc

The Efficacy and Safety of a Hybrid Hemostatic Device (ClearCoajet)

Project description:The ClearCoajet is a new hemostasis device with a hybrid function (Coagulation + Injection) and is developed to provide effective coagulation, injection, and marking around lesions without changing devices during the endoscopic procedure. In this study, the investigators examine the hemostatic effect of ClearCoajet on intraprocedural bleeding during endoscopic mucosal resection or endoscopic submucosal dissection for colorectal sessile polyps or lateral growth tumors larger than 1.5 cm. The investigators also aim to compare the delayed bleeding and recurrence rates between the ClearCoajet group and the control group.

| 9027 | ecrin-mdr-crc

Gene expression signatures of megakaryocytes post-IR

Project description:Platelets are anucleated blood cells that are produced by their progenitor cell, the megakaryocyte (MK). Platelets are centrally positioned in hemostasis and thrombosis and, according to the recent findings, play key roles in innate immunity, inflammation, atherogenesis, and cancer metastasis. The quantitative and qualitative properties of platelets are crucial determinants of their hemostatic function. While the regulatory mechanisms of platelet number and size have been studied separately, critical questions remain regarding the interplay of platelet number and size in hemostasis. In this study, using a mouse model of irradiation (IR)-induced thrombocytopenia, we show that mature MKs (mMKs) are resistant to IR and maintain the nadir platelet levels post IR. To identify the phenotype switching and function variation in BM MKs post IR, we performed microarray expression profiling of MKs from the bone marrow of mice at 1- or 3-days post IR and control mice (Ctrl).

2023-12-27 | GSE222512 | GEO

Platelet proteome dynamics in hibernating 13-lined ground squirrels

Project description:Hibernating mammals undergo a dramatic drop in temperature and blood flow during torpor and must suppress hemostasis to avoid stasis blood clotting. In addition, cold storage of most mammalian platelets induces cold storage lesions, resulting in rapid clearance following transfusion. 13-lined ground squirrels (Ictidomys tridecemlineatus) provide a model to study hemostasis and cold storage of platelets during hibernation because, even with a body temperature of 4-8C, their platelets are resistant to cold storage lesions. We quantified and systematically compared proteomes of platelets collected from ground squirrels at summer (activity), fall (entrance), and winter (topor) to elucidate how molecular-level changes in platelets may support hemostatic adaptations in torpor. Platelets were isolated from squirrel blood collected in June, October, and January. Platelet lysates from each animal were digested with trypsin prior to 11-plex tandem mass tag (TMT) labeling, followed by LC-MS/MS analysis for relative protein quantification. We found over 700 platelet proteins with significant changes over the course of entrance, torpor, and activity – including systems of proteins regulating translation, platelet degranulation, metabolism, complement, and coagulation cascades. We also noted species specific differences in hemostatic, secretory, and inflammatory regulators in ground squirrel platelets relative to human platelets. In addition to providing the first ever proteomic characterization of platelets from hibernating animals, our results support a model whereby systematic changes in metabolic, hemostatic, and other proteins support physiological adaptations in torpor. In addition, our results could translate into better methods to cold store human platelets, increasing their supply and quality for transfusions.

2021-12-08 | PXD026903 | Pride

Evaluation of usefulness of prophylactically hemostatic clipping for artificial ulcers after cold snare polypectomy for colonic polyps

Project description:Interventions: Cold snare polypectomy Hemostatic clipping after cold snare polypectomy Primary outcome(s): Bleeding rate after cold snare polypectomy. Study Design: Parallel Randomized

| 2633840 | ecrin-mdr-crc

ACUTE BLEEDING AND STORED RED BLOOD CELLS TRANSFUSION ATTENUATES LIVER REGENERATION FOLLOWING PARTIAL HEPATECTOMY

Project description:Our aim was to study the impact of bleeding and red blood cell (RBC) resuscitation on liver regeneration. We assessed the impact of RBC storage time on liver regeneration following 50% partial hepatectomy (PHx) in rats, and explored possible contributing molecular mechanisms using immunohistochemistry, RNA-Seq, and macrophage depletion.

2022-11-14 | GSE216924 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data