Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Handicraft classes for colorectal cancer patients with chemotherapy-induced neuropathy: improving neuropathic symptoms in hands through exercising the hand muscles

ABSTRACT: Background and study aims Chemotherapy-induced peripheral neuropathy (CIPN) is one of the common reasons that colorectal cancer patients cannot maintain their routine chemotherapy schedules. CIPN involves pain, numbness, tingling and sensitivity to cold in the hands and feet and is often very painful and stressful. Some medications are used for pain relief, but they are often not effective. As a result, there has been renewed interest in alternative therapies that stimulate the hand muscles, such as exercise or massage to relieve the neuropathic symptoms. This study aims to look at the effectiveness of a handicraft program as rehabilitation for colorectal cancer patients with CIPN, which involves basic craftwork to encourage the use of the minor muscles of the hands to make and decorate handicrafts. Who can participate? Adults with colorectal cancer who received chemotherapy What does the study involve? This rehabilitation program comes in the form of the handicraft class, which involves decorating crafts such as a hand mirror, a business card holder, a table clock, and a picture frame with lacquerware, using Korean traditional lacquerworks. This is performed once a week, for 2 hours per each session, for a total of 4 weeks. All volunteers will participate in same program. The effectiveness of this program will be evaluated by using a questionnaire.

DISEASE(S): Colorectal Cancer Treated With Chemotherapy

PROVIDER: 2412118 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

Normalization of cholesterol metabolism in spinal microglia alleviates neuropathic pain

Project description:Neuroinflammation is a major component in the transition to and perpetuation of neuropathic pain states. Spinal neuroinflammation involves activation of TLR4, localized to enlarged, cholesterol-enriched lipid rafts, designated here as inflammarafts. Conditional deletion of cholesterol transporters ABCA1 and ABCG1 in microglia, leading to inflammaraft formation, induced tactile allodynia in naïve mice. The apoA-I binding protein (AIBP) facilitated cholesterol depletion from inflammarafts and reversed neuropathic pain in a model of chemotherapy-induced peripheral neuropathy (CIPN) in wild-type mice, but AIBP failed to reverse allodynia in mice with ABCA1/ABCG1-deficient microglia, suggesting a cholesterol-dependent mechanism. An AIBP mutant lacking the TLR4-binding domain did not bind microglia nor reversed CIPN allodynia. The long-lasting therapeutic effect of a single AIBP dose in CIPN was associated with anti-inflammatory and cholesterol metabolism reprogramming and reduced accumulation of lipid droplets in microglia. These results suggest a cholesterol-driven mechanism of regulation of neuropathic pain by controlling TLR4 inflammarafts and gene expression program in microglia and blocking the perpetuation of neuroinflammation.

2021-04-16 | GSE154816 | GEO

αO-conotoxin GeXIVA[1,2] reduced neuropathic pain and changed gene expression in chronic oxaliplatin-induced neuropathy mice model

Project description:Chemotherapy induced peripheral neuropathy (CIPN) is a dose-limiting painful neuropathy that occurs commonly during cancer management, which often leads to the discontinuation of medication. Previous studies suggest that the α9α10 nicotinic acetylcholine receptor (nAChR) specific antagonist αO-conotoxin GeXIVA[1,2] is effective in CIPN models, however the related mechanisms remains unclear. Here we analyzed the preventive effect of GeXIVA[1,2] on neuropathic pain in the long-term oxaliplatin injection induced CIPN model. At the end of treatment, lumbar (L4-L6) spinal cord was extracted, and RNA-sequencing and bioinformatic analysis were performed to investigate the potential genes and pathways related to CIPN and GeXIVA[1,2]. GeXIVA[1,2] inhibited the development of mechanical allodynia induced by chronic oxaliplatin treatment. Repeated injections of GeXIVA[1,2] for 3 weeks have no effect on mice normal pain threshold or locomotor activity and anxiety-like behavior as evaluated in the open field test (OFT) and elevated plus maze (EPM). Our RNA-sequencing results identified 209 differentially expressed genes (DEGs) in CIPN model, simultaneously injection of GeXIVA[1,2] with oxaliplatin altered 53 of the identified DEGs. These reverted genes were significantly enriched in immune-related pathways represented by cytokine-cytokine receptor interaction pathway. Our findings suggest that GeXIVA[1,2] could be a potential therapeutic compound for chronic oxaliplatin induced CIPN management.

2024-01-18 | GSE253183 | GEO

Molecular Signatures of Muscle Rehabilitation After Limb Disuse

Project description:We have identified the molecular (transcriptional) signatures associated with muscle remodeling in response to rehabilitation in a patient cohort. Subjects with a closed malleolus fracture treated conservatively with 6 weeks of cast immobilization are recruited. Then subjects are enrolled in a 6 weeks structured rehabilitation program focusing on progressive resistance training of the ankle plantar flexor muscles. Phenotypic measurements are performed before (pre-rehab), during (mid-rehab, 3 weeks) and immediately after (post-rehab, 6 weeks) the rehabilitation intervention. The maximal cross-sectional area (muscle size) and peak torque (muscle strength) are quantified using isometric and isokinetic tests in combination with 3D-magnetic resonance imaging. Ankle plantar flexor muscle size and strength measurements are also performed on the uninvolved limb (serves as a control) at 4 months post-immobilization. Measurements are also acquired from the contralateral leg, which serves as an internal control.

2017-08-31 | GSE45462 | GEO

A Study of the Efficacy and Safety of PerOx Quench on the Prevention of Oxaliplatin Treatment Induced Neuropathy

Project description:Chemotherapy-induced peripheral neuropathy (CIPN) is a progressive, enduring, and often irreversible condition featuring pain, numbness, tingling and sensitivity to cold in the hands and feet (sometimes progressing to the arms and legs) that afflicts between 30 and 40 percent of patients undergoing chemotherapy. American Society of Clinical Oncology (ASCO) guidance on The Journal of Clinical Oncology (JCO, 2014 April 14) does not recommend any prophylaxis regimen for CIPN. PerOx Quench has unique membrane protection and anti-oxidative function as a special food, that’s why to try to explore its preventive effects on CIPN prevention induced by Oxaliplatin for colorectal cancer or gastric cancer chemotherapy.

| 2198947 | ecrin-mdr-crc

Is it possible to use home-based prehabilitation with added E-health in patients with colorectal cancer undergoing surgery?

Project description:Background and study aims Colorectal cancer is the third most common type of cancer worldwide, with the majority of the patients being >70 years of age. The main treatment, surgery, is associated with a high number of complications. Furthermore, many patients experience loss of quality of life after surgical treatment. Prehabilitation, optimization of a patient’s health status between diagnosis and major surgical intervention, seems to be effective in improving fitness. There are indications that a prehabilitation program that is personalized to the needs of a patient is most effective. Furthermore, a home-based prehabilitation program probably has the least impact on the patient’s life and is less demanding for high-risk patients (i.e. patients with low aerobic fitness), especially in the emotionally stressful period between diagnosis and surgery. On the other hand, supervision might be necessary to motivate and stimulate patients during their exercise routine. With modern technologies, already used in cardio-rehabilitation, such as teleprehabilitation, it is possible to monitor an exercise program remotely while the patient performs his training at home. The primary aim of this study is to investigate the feasibility of a home-based teleprehabilitation program in high-risk patients scheduled for cancer surgery. Who can participate? Adults over 18 years, with colorectal cancer requiring surgical treatment. What does the study involve? Participants are offered a teleprehabilitation program as part of their routine care in the weeks before surgery.

| 2421262 | ecrin-mdr-crc

Gene Expression Changes Associated with Respiratory Muscle Hypertrophy after Intermittent Transient Tracheal Occlusions

Project description:The effect of intermittent transient tracheal occlusion (ITTO) on gene expression was compared in the diaphragm and parasternal intercostals. We hypothesized that genes responsible for protein metabolism, myogenic activation, neuromuscular transmission, and inflammatory modulation would be altered in animals exposed to this rodent model of respiratory load compensation rehabilitation. Eight adult male Sprague-Dawley rats underwent placement of a tracheal occluder cuff and were divided into ITTO (n=4) or SHAM (n=4) treatment groups. Animals received 10 days of their assigned treatments. The day following the last treatment session, the animals were euthanized and the diaphragm and parasternals extracted. Messenger RNA was profiled with microarray analysis (Amadid: 028279, Agilent Technologies, Palo Alto, CA). Results were further analyzed with immunofluorescent examination of cross-sectional area and with quantitative reverse transcriptase polymerase chain reaction on a subset of genes exhibiting differential expression. The cross-sectional area of type IIx/b fibers was larger in the muscles of ITTO-trained animals. Microarray analysis identified 650 genes in the diaphragm and 1,181 genes in the intercostals that were differentially expressed between the groups (p<.01). In both muscles, biological processes for cell adhesion and chemical stimulus for the detection of olfaction biological processes were over-expressed. Additionally, we found significant differential expression of the g-protein signaling pathway and protein-amino acid phosphorylation in the intercostals. The results provide insight into neuromuscular plasticity associated with respiratory load compensation rehabilitation. Four experimental animals that received tracheal occlusions and four surgical control animals were used. Intercostal and diaphragm muscles were excised and analyzed separately.

2012-03-26 | E-GEOD-29574 | biostudies-arrayexpress

Chemical Sensors Detect and Resolve Proteome Aggregation in Peripheral Neuropathy induced by Chemotherapeutic Agents

Project description:Neuropathic pain, a consequence of somatosensory nervous system injury or disease, is commonly associated with cancer and its treatments, including chemotherapy-induced peripheral neuropathy (CIPN). However, the mechanisms underlying CIPN-induced proteome aggregation remain elusive due to limited detection tools. Here, we present a combined approach employing fluorescence imaging and proteomic sensors to comprehensively study proteome aggregation in neuronal cells subjected to CIPN. The AggStain imaging probe sensitively detected proteome aggregation, while the AggLink proteomic sensor captured and profiled aggregated proteins. This integrative sensor system offers novel insights into proteome aggregation dynamics in CIPN and highlights its potential for broader applications in assessing proteome stability under various conditions.

2023-10-09 | PXD045972 |

Exercise Effect on Chemotherapy-Induced Neuropathic Pain

Project description:Chemotherapy-induced peripheral neuropathy (CIPN) continues to be a serious healthcare concern. It is painful, persistent, resistant to conventional pain therapies, and results in long-term suffering and decreased quality of life for many cancer survivors. The role of exercise to decrease CIPN-related neuropathic pain (CIPN-NP) will be investigated, with the goal of identifying the mechanisms associated with this therapeutic approach to manage CIPN-NP.

| 2231977 | ecrin-mdr-crc

nuclear calcium regulated genes in spinal neurons during inflammatory pain

Project description:Identification of a pain-associated, nuclear calcium-regulated gene program in spinal excitatory neurons during inflammatory pain, using a nucleus-specific calcium signal perturbation strategy in vivo complemented by gene profiling

2013-12-13 | E-MTAB-1416 | biostudies-arrayexpress