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Influence of two different resection techniques of liver metastases from colorectal cancer on haematogenous tumour cell dissemination

ABSTRACT: Study hypothesis: We hypothesise that intraoperative haematogenous tumour cell dissemination could be reduced or prevented by using the anterior approach technique in resection of colorectal liver metastases. Please note that as of 11/02/2009 this record was updated to include an amended end date. The initial end date at the time of registration was: Initial anticipated end date: 28/02/2009 Primary outcome(s): To compare the anterior approach to the conventional technique of hepatic resection for colorectal metastases with respect to the incidence of intraoperative haematogenous tumour cell dissemination. We hypothesise that intraoperative haematogenous tumour cell dissemination could be reduced or prevented by using the anterior approach technique in resection of colorectal liver metastases.

DISEASE(S): Liver Cancer

PROVIDER: 2417868 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Project description:The paper describes a model of tumour-induced neoneurogenesis and perineural tumour growth. Created by COPASI 4.25 (Build 207) This model is described in the article: Tumour-induced neoneurogenesis and perineural tumour growth: a mathematical approach Georgios Lolas, Arianna Bianchi and Konstantinos N. Syrigos Scientific Reports 6:20684 Abstract: It is well-known that tumours induce the formation of a lymphatic and a blood vasculature around themselves. A similar but far less studied process occurs in relation to the nervous system and is referred to as neoneurogenesis. The relationship between tumour progression and the nervous system is still poorly understood and is likely to involve a multitude of factors. It is therefore relevant to study tumour-nerve interactions through mathematical modelling: this may reveal the most significant factors of the plethora of interacting elements regulating neoneurogenesis. The present work is a first attempt to model the neurobiological aspect of cancer development through a system of differential equations. The model confirms the experimental observations that a tumour is able to promote nerve formation/elongation around itself, and that high levels of nerve growth factor and axon guidance molecules are recorded in the presence of a tumour. Our results also reflect the observation that high stress levels (represented by higher norepinephrine release by sympathetic nerves) contribute to tumour development and spread, indicating a mutually beneficial relationship between tumour cells and neurons. The model predictions suggest novel therapeutic strategies, aimed at blocking the stress effects on tumour growth and dissemination. To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models . To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

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Influence of two different resection techniques of liver metastases from colorectal cancer on haematogenous tumour cell dissemination

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