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CanChange: A psychosocial and lifestyle intervention for colorectal cancer survivors

ABSTRACT: Interventions: Participants in the intervention arm will receive a telephone-delivered lifestyle and psychosocial supportive care program. The program will be delivered over 6 months and include up to 12 sessions two weeks apart for approximately 30 minutes each. Primary outcome(s): Quality of Life: Short Form 36 (SF-36)[Baseline, 6 and 12 months];Psychological adjustment: Hospital Anxiety and Depression Scale (HADS)[Baseline, 6 and 12 months] Study Design: Purpose: Treatment; Allocation: Randomised controlled trial; Masking: Blinded (masking used);Assignment: Parallel;Type of endpoint: Safety/efficacy

DISEASE(S): Colorectal Cancer,Cancer-bowel-back Passage (rectum) Or Large Bowel (colon)

PROVIDER: 2454111 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Project description:SF-1, a transcription factor belonging to the nuclear receptor superfamily, has a pivotal role for adrenogonadal development in humans and mice. A constant feature of childhood adrenocortical tumors (ACT) is SF-1 amplification and overexpression. Using an inducible cellular system, here we show that SF-1 overexpression increases human adrenocortical cell proliferation through opposing effects on cell cycle and apoptosis. SF-1 overexpression also selectively modulates steroidogenesis, reducing cortisol and aldosterone secretion. We identified a novel pro-apoptotic factor for adrenocortical cells, NOV/CCN3, whose levels are significantly reduced by SF-1 overexpression in human adrenocortical cells and are also reduced in primary adrenal tumors. Moreover, Sf-1 overexpression triggers adrenocortical hyperplasia and tumor formation in mice. These tumors express gonadal markers and activated Stat3. Our studies reveal the critical role of SF-1 gene dosage for adrenocortical tumorigenesis and constitute a rationale for the development of drugs targeting SF-1 transcriptional activity for ACT therapy. Keywords: comparative gene expression Gene expression profiles were analyzed by two-color microarrays in transgenic mice from line #56 heterozygous or homozygous for the transgene, male or female and of different ages. Profiles from each transgenic mouse were directly compared to a sex- and age-matched wild-type littermate. For each experimental point, two technical replicates (dye-swaps) were examined. Array # Age Sex Transgene copy # Cy3 Cy5 16682 10 days M 1 WT transgenic 16479 10 days M 1 transgenic WT 16683 10 days M 1 WT transgenic 16625 10 days M 1 transgenic WT 16685 10 days F 1 WT transgenic 16680 10 days F 1 transgenic WT 16516 4 months M 2 WT transgenic 16452 4 months M 2 transgenic WT 16517 4 months M 2 WT transgenic 16453 4 months M 2 transgenic WT 16518 4 months F 2 WT transgenic 16475 4 months F 2 transgenic WT

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CanChange: A psychosocial and lifestyle intervention for colorectal cancer survivors

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