Dataset Information

A survey of participants enrolled in the Southern Co-Operative Program for the Prevention of Colorectal Cancer (or SCOOP program) to assess attitudes toward their current surveillance intervals and methods.

ABSTRACT: Interventions: Eligible participants will be those who are part of The Southern Co-operative Program for the Prevention of Colorectal Cancer (SCOOP) program run through Southern Adelaide Local Health Network and who already receive surveillance for colorectal cancer through regular colonoscopy and faecal occult blood tests (FOBT). All patient details are entered into a clinical recall database. As part of SCOOP, risk profiles of all registrants are continually reviewed and updated to ensure that all have been assigned a CRC risk level that is accurate and reflects current knowledge. We will screen the recall database to exclude those who have had CRC in the past or currently, are deceased and those who are under the age of 18 or over the age of 75 years. Following this, there will be a random selection of 800 people from the database who receive FOBTs and regular colonoscopies. The randomly selected invitees will be posted an invitation pack containing Letter of Invitation, an Opt-Out slip, the survey and a reply paid envelope. A reminder letter will be send after 4 weeks to all those who did not complete the survey or the Opt-Out slip.The survey will take approximately 20 minutes to complete. Primary outcome(s): Enrolee attitudes towards different scenarios of timings for bowel cancer surveillance methods. This will be assessed with questions within a survey that have been specifically designed for this study.[Assessed at single survey.];Enrolee preferences for different methods for bowel cancer surveillance. This will be assessed with the Quality of Colorectal Cancer Screening Decisions instrument (CRC-DQI) as published by Sepucha et al (2014), and a five-factor general colorectal cancer screening model as published by Tiro et al (2005).[Assessed at single survey] Study Design: Purpose: Psychosocial;Duration: Cross-sectional;Selection: Defined population;Timing: Prospective

DISEASE(S): Public Health-health Service Research,Colorectal Cancer,Cancer-bowel-back Passage (rectum) Or Large Bowel (colon)

PROVIDER: 2467672 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Project description:Interventions: Colorectal cancer (CRC) prevention programs are tailored to the degree of risk and within the Australian public health system with surveillance by colonoscopy usually reserved for those in the above average risk category. Different levels of risk, average, moderately increased and high, are recognised for population sub-groups. All potential participants will be taken from the ‘Southern Cooperative Program for the Prevention of Colorectal Cancer’ (SCOOP) which is a clinical database which consisting of individuals with a family history of CRC or a personal history of neoplasia, and who have their surveillance colonoscopies through two South Australian public hospitals and selected private hospitals. Commencing in 1999, this program currently has 7000 people enrolled and is made up of gastroenterologists, geneticists, nurses and support administrative staff and is coordinated from the Bowel health Service (BHS) at Flinders Centre for Innovation in Cancer (FCIC), Flinders Medical Centre. SCOOP also has a research arm to help improve the program and improve patient outcomes. It is estimated that there will be 4,500 eligible individuals from the SCOOP population, who will have a surveillance colonoscopy planned between the 2019 and 2023. Colonoscopy intervals are decided by the SCOOP team of specialists in conjunction with the National Health and Medical Research Council (NHMRC) ‘Clinical practice guidelines for surveillance colonoscopy’ 2018. As part of the program, SCOOP individuals are provided with a ‘Faecal Immunochemical Test’ (FIT) kit in the interval between their 3 or 5 yearly colonoscopies. Those with a 3 year colonoscopy interval will have an offer of FIT at 1 year and those with a 5 year colonoscopy interval will have an offer of FIT at 1 yea Primary outcome(s): To determine the safety of extending colonoscopy schedules by one-third, in intervention arm, by including interval Faecal Immunochemical Test (FIT) as evidenced by the decreased presence of advanced neoplasia as assessed by colonoscopy.[Group 1: Intervention arm - Assessed 6 months post colonoscopy.];Burden of having a colonoscopy as assessed by study-specific colonoscopy costing survey. [All participants in Group 1 only: Assessed 6 months post colonoscopy.] Study Design: Purpose: Prevention; Allocation: Randomised controlled trial; Masking: Open (masking not used);Assignment: Other;Type of endpoint: Efficacy

Project description:Interventions: We propose to conduct a prospective observational study to investigate how change in diet and lifestyle patterns over time impacts the development of precancerous colorectal lesions or colorectal cancer in individuals at above average risk of colorectal cancer and undergoing a colonoscopy surveillance - the ‘Southern Cooperative Program for the prevention of colorectal cancer’ (SCOOP). Data regarding patients’ colonoscopies will be extracted from the SCOOP database. Participants enrolled in the SCOOP program will be invited to complete the diet and lifestyle survey over the period of three years (in years 1 (baseline survey), 2 and 3 (follow-up surveys)). The survey can be completed by the participants either online, by clicking on a provided link or scanning a QR code. It is expected that each survey will require around 40-50 minutes to be filled out. The exposure variables include: -Dietary intake (using a validated food frequency questionnaire from the Australian Eating Survey), -Physical activity (using the International Physical Activity Questionnaire (IPAQ-L)), -Sleep patterns (Pittsburgh Sleep Quality Index (PSQI), Obstructive sleep apnoea screening questionnaire (OSAS), and Insomnia Severity Index questionnaire, -Smoking status, -Body mass index (BMI), -Aspirin intake, and -Comorbidities including diabetes. Primary outcome(s): The primary outcome of this study will be the dietary pattern that will be assessed using a validated food frequency questionnaire. [This will be assessed at baseline (year 1), years 2 and 3 at anytime during the three year observation period. Individuals whose colonoscopies are due within one year will receive only one diet survey (baseline), while those whose colonoscopies are due in two years’ time will receive only two diet surveys before their next scheduled colonoscopy. Most patients under surveillance will receive regular colonoscopies at intervals of 3 or 5 years, and they will be able to take part in all three diet surveys until the next scheduled colonoscopy.];Another primary outcome of this study will be sleep quality assessed by a validated International Physical Activity Questionnaire (IPAQ-L). [This will be assessed at baseline (year 1), years 2 and 3 at anytime during the three year observation period. Individuals whose colonoscopies are due within one year will receive only one physical activity survey (baseline), while those whose colonoscopies are due in two years’ time will receive only two physical activity surveys before their next scheduled colonoscopy. Most patients under surveillance will receive regular colonoscopies at intervals of 3 or 5 years, and they will be able to take part in all three physical activity surveys until the next scheduled colonoscopy.];Another primary outcome of this study will be sleep quality assessed by a validated Pittsburgh Sleep Quality Index (PSQI). [This will be assessed at baseline (year 1), years 2 and 3 at anytime during the three year observation period. Individuals whose colonoscopies are due within one year will receive only one sleep survey (baseline), while those whose colonoscopies are due in two years’ time will receive only two sleep surveys before their next scheduled colonoscopy. Most patients under surveillance will receive regular colonoscopies at intervals of 3 or 5 years, and they will be able to take part in all three sleep surveys until the next scheduled colonoscopy.] Study Design: Purpose: Screening;Duration: Longitudinal;Selection: Defined population;Timing: Prospective

Project description:Interventions: Colorectal cancer (CRC) prevention programs are tailored to the degree of risk and within the Australian public health system with surveillance by colonoscopy usually reserved for those in the above average risk category. Different levels of risk, average, moderately increased and high, are recognised for population sub-groups. People with known genetic syndromes (eg familial adenomatous polyposis [FAP], hereditary nonpolyposis colorectal cancer [HNPCC, also known as Lynch Syndrome] are considered to be at high risk for CRC and are advised to undergo regular (every 1-2 years) colonoscopic surveillance. We propose to conduct this uncontrolled observational study, where patients self-select to the treatment group based on their participation in a colonoscopy surveillance program - the ‘Southern Cooperative Program for the prevention of colorectal cancer’ (SCOOP), run through Flinders Medical Centre and Noarlunga Hosptial. We will approach SCOOP patients and offer a FIT (Faecal Occult Blood Test) to be completed 1 - 2 weeks prior to their scheduled colonoscopy to determine the positive predictive value (PPV), negative predictive value (NPV), specificity and sensitivity for neoplasia of FIT, in comparison to colonoscopy. The FIT kit including an invitation letter, two collection tubes, instructions and a reply paid envelope, will be posted to study invitees. Participants will be required to self-collect two small stool samples (approximately 10mg of stool which is smaller than a grain of rice) with the provided collection devices. The samples will then be placed in the collection tubes, placed in a reply paid envelope and posted back to the testing laboratory. Following return to the testing laboratory, samples will be analysed for levels of faecal haemo Primary outcome(s): Faecal haemoglobin level as assessed by FIT test.[assessed within 1 - 2 weeks before the colonoscopy] Study Design: Purpose: Screening;Duration: Cross-sectional;Selection: Defined population;Timing: Prospective

Project description:Co-fractionation mass spectrometry (CF-MS) is a technique with potential to characterise endogenous and unmanipulated protein complexes on an unprecedented scale. However this potential has been offset by a lack of guidelines for best-practice CF-MS data collection and analysis. To obtain such guidelines, this study exploits very high proteome coverage libraries of gold standard Saccharomyces cerevisiae complexes to thoroughly evaluate novel and published yeast CF-MS datasets. A new method for identifying gold standard complexes in CF-MS data, Reference Complex Profiling, and the Extending ‘Guilt-by-Association’ by Degree (EGAD) R package are used for these evaluations, which are reinforced with concurrent analyses of published human data. By evaluating data collection designs, which involve fractionation of cell lysates, it is found that near-maximum recall of complexes can be achieved with fewer samples than published studies. Distributing sample collection across orthogonal fractionation methods, rather than a single high resolution dataset, leads to particularly efficient recall. By evaluating 17 different similarity scoring metrics, which are central to CF-MS data analysis, it is found that two metrics rarely used in past CF-MS studies – Spearman and Kendall correlations – and the recently introduced Co-apex metric frequently maximise recall, while a popular metric – Euclidean distance – delivers poor recall. The common practice of integrating external genomic data into CF-MS data analysis is also evaluated, revealing that this practice may improve the precision and recall of known complexes but is generally unsuitable for predicting novel complexes in model organisms. If studying non-model organisms using orthologous genomic data, it is found that particular subsets of fractionation profiles (e.g. the lowest abundance quartile) should be excluded to minimise false discovery. Together these guidelines identify avenues for precise, sensitive and efficient CF-MS studies of known complexes, and effective predictions of novel complexes for orthogonal experimental validation.

Dataset Information

A survey of participants enrolled in the Southern Co-Operative Program for the Prevention of Colorectal Cancer (or SCOOP program) to assess attitudes toward their current surveillance intervals and methods.

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