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The effects of foot reflexology on fatigue among cancer patients undergoing chemotherapy

ABSTRACT: Intervention 1: In the intervention group, foot reflexology massage will be performed in 4 courses of chemotherapy in patients with colorectal cancer and the fatigue will be measured before and after each massage. At the end of the work, these two groups will be compared, ie, intervention and control. Intervention 2: Control group: routine care was performed and before and after each chemotherapy simultaneously with the massage, the fatigue was measured.;Treatment - Other;Treatment - Other;Control group: routine care was performed and before and after each chemotherapy simultaneously with the massage, the fatigue was measured;In the intervention group, foot reflexology massage will be performed in 4 courses of chemotherapy in patients with colorectal cancer and the fatigue will be measured before and after each massage. At the end of the work, these two groups will be compared, ie, intervention and control Primary outcome(s): Fatigue. Timepoint: Before intervention, after intervention. Method of measurement: Florida inventory for fatigue symptom and Piper Fatigue Questionnaire. Study Design: Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Randomization description: In this research, convenience sampling method and random allocation method were used. Researchers went to selected centers daily and using random numbers table, the study samples were allocated to groups A or B. This process continued until 30 samples per group and a total of 60 samples were obtained.

DISEASE(S): Colorectal Cancer,Malignant Neoplasm Of Anus And Anal Canalc18malignant Neoplasm Of Colon, C19malignant Neoplasm Of Rectosigmoid Junction, C20malignant Neoplasm Of Rectum, C21

PROVIDER: 2493920 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Project description:Individuals affected by post-covid condition (PCC) show an increased fatigue and the so-called post-exertion malaise (PEM) that led health professionals to advise against exercise although accumulating evidence indicate the contrary. The goal of this study is to determine the impact of a closely monitored 8-week mixed exercise program on physical capacity, symptoms, fatigue, systemic oxidative stress and plasma proteomic profiles of PCC cases. Methods: Twenty-five women and men with PCC assigned sequentially to exercise (n = 15) and non-exercise (n = 10) groups. Individuals with no PCC served as a control group. The exercise program included cardiovascular and resistance exercises. Physical capacity, physical activity level and the presence of common PCC symptoms were measured before and after the intervention. Fatigue was measured the day following each exercise session. Plasma and PBMC samples were collected at the beginning and end of the training program. Glutathione and deoxyguanosine levels in PBMC and plasma proteomic profiles were evaluated. Results: Bicep Curl (p=0.040) and STS-30 (p=0.043) improved to a greater extent in the exercise group than in the non-exercise group. An interaction effect was also observed for the level of physical activity (p=0.007) with a positive effect of the program on their daily functioning and without any adverse effects on general or post-effort fatigue. Glutathione levels showed marked improvement after exercise. Discernable changes were observed in the plasma proteomics profile with certain proteins involved in inflammatory response (SA100A8) decreasing in the exercise group. Conclusion: Supervised exercise adapted to the level of fatigue and ability is safe and effective in PCC patients in improving their general physical capacity and wellbeing. Systemic molecular markers that accompany physical improvement can be monitored by analyzing plasma proteomics and markers of oxidative stress. Large-scale studies will help identify promising molecular markers to objectively monitor patient improvement.

Project description:Massage therapy is commonly used for the physical rehabilitation of skeletal muscle to ameliorate pain and promote recovery from injury. While there is some evidence that massage may relieve pain in injured muscle, the cellular effects remain unknown. To assess the effects of massage, we administered either massage therapy or no treatment to separate quadriceps of eleven young, male participants after exercised-induced muscle damage. Muscle biopsies were acquired from the quadriceps (vastus lateralis) at baseline (rest), immediately after 10 minutes of massage treatment (0h), and after a 2.5 hour period of recovery. We found that massage activated the mechanotransduction signaling pathways FAK and Erk1/2, potentiated mitochondrial biogenesis signaling (nuclear PGC-1α), and mitigated the rise in NFkB (p65) nuclear accumulation caused by muscle trauma. Moreover, in spite of having no effect on muscle metabolites (glycogen, lactate), massage attenuated the production of the inflammatory cytokines TNF-α and IL-6 and reduced HSP27 phosphorylation, effectively mitigating cellular stress resulting from myofiber injury. In summary, massage therapy appears to be clinically beneficial when administered to acutely damaged skeletal muscle by reducing inflammation and promoting mitochondrial biogenesis. 55 muscle biopsies were used in this study as material to evaluate the effects of massage on gene expression. These biopsies were taken from the vastus lateralis of eleven healthy recreationally active males with full ethical approval at McMaster's university. Each individual had an initial biopsy at rest (baseline), followed by exercist testing for peak aerobic capacity. On a second visit, the individual performed a bout of exhaustive aerobic exercise, prior to recieving a randomized massage treatment to one leg. Immediatley following the exercise, subjects were allowed to recover for 10 minutes, while massage oil was lightly applied to both quadriceps. Then a single leg was randomized to recieve massage treatment for 10 minutes. Subjects then rested for 10 minutes, and one additional biopsies were carried out (on each leg). Two and half hours later (3 hours after the cessation of the exercise bout), 2 more biopsies were taken (one from each leg). This amounted to 5 biopsies from each individual.

Project description:Interventions: The measurements will be taken before and after 8 weeks of intervention in 20 participants who will be randomly divided in a counterbalanced manner into two groups: Training (TG) and Control (CG). A researcher will perform the data collection in a blinded manner. The intervention will be performed only in the training group, in order to analyze the effectiveness of muscle co-contraction training on levels of maximum torque, muscle thickness, fatigue conditions and quality of life, and the expression of miRNAs. This training will be supervised by a Physical Education Professional in a virtual way. The CG group, on the other hand, will not perform the co-contraction training and will maintain the physical activities they already performed previously.For the muscle co-contraction training, the Physical Education Professional will send a Google Meet link to the participants. Meetings will occur virtually twice a week for eight weeks. The interval defined between one training session and another will be a minimum of 72 hours and a maximum of 96 hours. In all the meetings to be held with the research participants, the Physical Education Professional responsible for supervising the training will make sure that the participants have the camera open for safety reasons and to make postural corrections if necessary. Once positioned, the participants will receive the verbal instruction Try to contract your biceps and triceps simultaneously as hard as you can without your forearm moving and Try to contract your quadriceps and hamstrings simultaneously as hard as you can without your leg moving for the elbow and knee co-contractions, respectively. Each volunteer will have the opportunity to perform two five-second co-contractions (on each of the two exercises) for familiarization;G11.427.410.698.277 Primary outcome(s): After intervention, we expect a significative increase in the maximum isometric torque (Nm) of knee and elbow extension and flexion, measured by an isokinetic dynamometer equipment (Biodex, System 4 Pro, New York, NY, USA) with an acquisition frequency of 100 Hz.

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The effects of foot reflexology on fatigue among cancer patients undergoing chemotherapy

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