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Investigation of exercise effect to reduce symptoms of peripheral neuropathy caused by chemotherapy

ABSTRACT: Interventions: Behavioral : As an intervention that provides a physical activity program to alleviate the symptoms of peripheral neuropathy caused by anticancer drugs, it consists of the following contents. -Provides a physical activity program application that includes exercise videos for 6weeks - Phone consultation once a week (for 4 weeks) Primary outcome(s): Chemotherapy-induced peripheral neuropathy symptom;Interference with activities; Quality of life;Intervention compliance Primary Purpose : Supportive Care, Intervention Model : Parallel, Blinding/Masking : Single, Blinding Target : Investigator, Allocation : RCT

DISEASE(S): Neoplasms

PROVIDER: 2514148 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Gene expression changes in Peripheral Blood Mononuclear cells (PBMC) induced by physical activity

Project description:Gene expression changes in Peripheral Blood Mononuclear cells (PBMC) induced by physical activity was investigated in sedentary middle-aged men (mean age 52.6 years and BMI 29.1) who undertook a 24-week physical activity programme with blood sampling in the pre-exercise period , at the end of 24-weeks prescribed physical activity , and following a two-week detraining period. AgilentTM Whole Human Genome Oligo Microarrays were utilised to examine the effects of physical activity on mRNA expression profiles of the Peripheral Blood Mononuclear cells (PBMC) at 3 time points (pre-exercise, after 24 weeks physical activity, and at 26 weeks after 2 weeks detraining. There were 12 participants in this programme.

2010-08-03 | E-GEOD-12385 | biostudies-arrayexpress

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Effect of IL6 level on gene expression changes in Peripheral Blood Mononuclear cells (PBMC) induced by physical activity

Project description:A number of chronic, age-related diseases are associated with elevated markers of inflammation such as interleukin-6 (IL-6). In this study, we investigated the hypothesis that sedentary individuals with disparate basal serum IL-6 respond differentially to a structured physical activity programme. Gene expression changes in Peripheral Blood Mononuclear cells (PBMC) induced by physical activity was investigated in sedentary, middle-aged men (mean age 52.6 years and BMI 29.1), with relatively high or low basal serum IL-6 levels (mean of 2.13 and 0.59pg/ml respectively), who undertook a 24-week physical activity programme with blood sampling in the pre-exercise period and at the end of 24-weeks prescribed physical activity. AgilentTM Whole Human Genome Oligo Microarrays were utilised to examine the effects of physical activity on mRNA expression profiles of the Peripheral Blood Mononuclear cells (PBMC) at 2 time points (pre-exercise, and after 24 weeks physical activity. There were 6 individuals per group.

2010-08-03 | E-GEOD-12384 | biostudies-arrayexpress

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Project description:Objective: To evaluate gene expression profiles in multiple sclerosis (MS) patients who improved their fatigue status after a program of physical exercise and to compare them with healthy controls (HC). Methods: A prospective longitudinal study was conducted. Gene expression in whole blood was profiled at baseline in 7 healthy controls and also in 7 fatigued-MS patients. Patients underwent a physical exercise program for 6 months, and their fatigue status and gene expression profiles were again analyzed at the end of this program. Results: MS patients showed a significant activation of genes participating in the systemic interferon response in comparison with healthy controls. Fatigue improved at the end of the physical activity program, and, in parallel, systemic activation of interferon related genes disappeared. Conclusions: Fatigue improvement following an exercise program is associated to down modulation of interferon activity at the systemic level in MS patients. Our results provide a biological basis for the observed benefit of physical exercise in MS.

2015-09-27 | E-MTAB-2973 | biostudies-arrayexpress

Expression Data for Cisplatin Treated Dorsal Root Ganglia from A/J and C57BL/6J Mice

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Rat DRG CIPN versus Vehicle-treatment_DIA-MS

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2022-03-24 | PXD028356 | Pride

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2020-04-14 | E-MTAB-8956 | biostudies-arrayexpress

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Gene expression changes in Peripheral Blood Mononuclear cells (PBMC) induced by physical activity

2010-08-03 | GSE12385 | GEO

Transcriptomes of peripheral blood mononuclear cells from a Guillain-Barre Syndrome patient and her healthy twin sampled at three different points of the disease evolution

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