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A Phase 1b/2 Open Label, Dose Escalation Study of AMG 655 in Combination with AMG 479 in Subjects with Advanced, Refractory Solid Tumors.--------------------------------------------------------Estudio abierto de fase 1b/2 con escalada de dosis de AMG 655 en combinación con AMG 479 en sujetos con tumores sólidos refractarios y avanzados.

ABSTRACT: Primary objectives: Part 1: To identify a dose of AMG 655 in combination with AMG 479 that is safe andtolerated as determined by the incidence of dose limiting toxicity (DLT).Part 2: To estimate the efficacy, as measured by the objective response rate (ORR;confirmed complete response [CR] and partial response [PR] using modified Response Evaluation Criteria in Solid Tumors [RECIST]) of AMG 655 in combination with AMG 479. Primary endpoints: Part 1: The incidence of adverse events and clinical laboratory abnormalities defined as DLTPart 2: ORR (confirmed CR and PR, by modified RECIST)

DISEASE(S): Ovarian Cancer,Part 1: Advanced, Treatment-refractory Solid Tumorspart 2: Advanced Non-small Cell Lung Cancer (nsclc), Colorectal Cancer (crc), Pancreatic Cancer, Ovarian Cancer, Or Sarcoma.------------------------------------------------------------parte 1:tumores Sólidos Refractarios Y Avanzados.parte 2:cáncer De Pulmón No Microcítico Avanzado (cpnm), Cáncer Colorrectal (crc), Cáncer Pancreático, Cáncer De Ovario O Sarcoma.,Colorectal Cancer,Part 1: Advanced, Treatment-refractory Solid Tumorspart 2: Advanced Non-small Cell Lung Cancer (nsclc), Colorectal Cancer (crc), Pancreatic Cancer, Ovarian Cancer, Or Sarcoma.--------------------...,Pancreatic Cancer

PROVIDER: 2525060 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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