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A study to evaluate CM24 in combination with nivolumab in adults with solid tumours

ABSTRACT: Primary objectives: Part A• To assess the safety, tolerability and the maximum tolerated dose (MTD) of CM24 in combination with 480mg nivolumab in adults with selected recurrent or metastatic solid tumors.• Determine the recommended Phase 2 dose level (RP2D) of CM24 in combination with nivolumab Part BTo assess the efficacy of the recommended phase 2 dose (RP2D) of CM24 in combination with nivolumab in adults with immune-checkpoint refractory recurrent or metastatic NSCLC based on Objective Response Rate (ORR). Part CTo assess the efficacy of CM24 in combination with nivolumab and nabpaclitaxel in adults with metastatic pancreatic cancer based on Objective Response Rate. Primary endpoints: Part ASafety and tolerability Parts B and CObjective response rate (ORR) based on RECIST Version 1.1

DISEASE(S): Ovarian Cancer,Colorectal Adenocarcinoma,Part A- Recurrent And Metastatic Non-small Cell Lung Cancer (nsclc), Pancreatic Cancer, Ovarian Cancer, Papillary Thyroid Cancer, Colorectal Adenocarcinoma And Melanomapart B- Recurrent Or Metastatic Immune Checkpoint Refractory Nsclcpart C- Metastatic Pancreatic Cancer,Papillary Thyroid Cancer,Non-small Cell Lung Cancer,Part A- Recurrent And Metastatic Non-small Cell Lung Cancer (nsclc), Pancreatic Cancer, Ovarian Cancer, Papillary Thyroid Cancer, Colorectal Adenocarcinoma And Melanomapart B- Recurrent Or Metasta...,Pancreatic Cancer,Malignant Melanoma,Parte A- Cáncer De Pulmón No Microcítico (cpnm) Metastásico Y Recurrente, Cáncer De Páncreas, Cáncer De Ovario, Cáncer Papilar Tiroideo, Adenocarcinoma Colorrectal Y Melanomaparte B- Cpnm Resistente A Los Puntos De Control Inmunitario Recurrente O Metastásicoparte C- Cáncer De Páncreas Metastásico

PROVIDER: 2540836 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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