Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A comparison of keyhole surgeries vs traditional open surgeries for large intestinal cancers.

ABSTRACT: Primary outcome(s): 1. Circumferential margin (positive/negative) 2. Proximal margin (in cms) 3. Distal margin (in cms) 4. Number of lymph nodes retrieved (number) -Timepoint: 1 year 9 months

DISEASE(S): Malignant Neoplasm Of Rectum

PROVIDER: 2592967 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

Predicting response to chemotherapy in rectal cancer

Project description:Neoadjuvant chemoradiotherapy (CRT) is used in locally advanced rectal cancer when tumours threaten the circumferential resection margin. A variable response to treatment remains, notwithstanding potentially significant morbidity, and no clinically routinely used predictive biomarkers guide decision making. This experimental study aimed to identify significantly differentially expressed proteins between patients responding or not to CRT, using novel temporal proteomic profiling, and to validate any proteins of interest.

2018-03-12 | PXD008436 | Pride

Greifswalder microbiome analysis colorectal cancer

Project description:Interventions: Group 1: Arm 1 - colon cancer -> 16sRNA microbiome analysis (stool at time of initial diagnosis/ stool post operative/ stool during follow up; healthy normal tissue of the proximal and distal resection margin; tumor tissue) Group 2: Arm 2 - rectal cancer -> 16sRNA microbiome analysis (stool examination at time of initial diagnosis/ if neoad. therapy than stool examination after completion of neoadj. therapy/ stool examination post operative and during follow up; healthy normal tissue of the proximal and distal resection margin; tumor tissue) Primary outcome(s): 16sRNA analysis of the microbiome (stool at initial diagnosis and postoperatively at primary surgery, or before neoadj. therapy and after completion, tumor tissue intraoperatively) in patients with CRC. Study Design: Allocation: ; Masking: ; Control: ; Assignment: ; Study design purpose: other

| 2439238 | ecrin-mdr-crc

Lymph node retrieval using fat dissolution technique after surgical resection of colorectal cancer

Project description:Interventions: Application of fat dissociation method on the resected mesentery of colon and rectum. Lymph nodes will be searched for after fat dissolution. Primary outcome(s): Comparison of the number of retrieved lymph nodes obtained by conventional method and that obtained by new method Study Design: Single arm Non-randomized

| 2644634 | ecrin-mdr-crc

The efficacy of ImofullyTM in lymph node retrieval for pathological examination after surgical resection of colorectal cancer

Project description:Interventions: After lymph node retrieval with conventional method, lymph node retrieval was performed again after fat dissolution with Imofully Primary outcome(s): The number of the additionally retrieved lymph nodes after fat dissolution Study Design: Single arm Non-randomized

| 2639145 | ecrin-mdr-crc

Quantitative Mass Spectrometry Analysis of the Injured Proximal and Distal Human Digital Nerve Ends

Project description:Proteomic analysis of injured human peripheral nerves, particularly focusing on events occurring in the proximal and distal nerve ends, remains relatively underexplored. This study aimed to investigate the molecular patterns underlying a digital nerve injury, concentrating on differences in protein expression between the proximal and distal nerve ends. A total of 26 human injured digital nerve samples (24 men; 2 women; median age 47 [30-66] years), harvested during primary nerve repair within 48 hours post-injury from proximal and distal nerve ends, were analyzed using mass spectrometry. A total of 3914 proteins were identified, with 127 proteins showing significant differences in abundance between the proximal and the distal nerve ends. The downregulation of proteins in the distal nerve end was associated with synaptic transmission, autophagy, neurotransmitter regulation, cell adhesion and migration. Conversely, proteins upregulated in the distal nerve end were implicated in cellular stress response, neuromuscular junction stability and muscle contraction, neuronal excitability and neurotransmitter release, synaptic vesicle recycling and axon guidance and angiogenesis. Investigation of proteins, with functional annotations analysis, in proximal and the distal ends of human injured digital nerves, revealed dynamic cellular responses aimed at promoting tissue degeneration and restoration, while suppressing non-essential processes.

2024-07-19 | PXD051266 | Pride

Randomized Trial of Primary Surgery Followed Selective Radiochemotherapy for Rectal Cancer With MRI Negative CRM

Project description:The purpose of this study is to determine whether primary radiotherapy can be omitted for the locally advanced rectal cancer with Magnetic Resonance Imaging (MRI) negative circumferential margin.

| 2165294 | ecrin-mdr-crc

Transcription profiling of human acute appendicitis

Project description:Gene expression was evaluated in 9 appendix samples removed from patients who went to the operating room with the diagnosis of acute appendicitis and 4 samples removed for non-inflammatory reasons. A circumferential piece of tissue was obtained at the distal aspect of each specimen. The tissue was flash frozen at -80 degrees for later processing. Frozen specimens were homogenized into TriReagent and RNA was isolated according to the manufacturerâs instruction. RNA was processed and hybridized to Affymetrix microarray. Experiment Overall Design: 9 patients and 4 controls

2008-06-16 | E-GEOD-9579 | biostudies-arrayexpress

Gene expression profiling in proximal versus distal mouse colon

Project description:Analysis of gene expression in proximal versus distal part of the mouse large intestine. Three (3) animals (biological replicates) were used to isolate tissue from proximal and distal areas of the large intestine.

2015-01-01 | E-GEOD-64423 | biostudies-arrayexpress

Large 1p36 deletions affecting Arid1a locus facilitate Mycn-driven oncogenesis in a new neuroblastoma model

Project description:Loss of heterozygosity (LOH) at 1p36 is a frequent chromosomal event in a broad range of human cancers with increased incidence observed in nervous system malignancies, including neuroblastoma (NBL). MYCN amplification and 1p36 deletions are highly correlated markers of tumor aggressiveness in NBL. While short distal 1p36 losses are associated with single copy MYCN tumors, larger hemizygous 1p deletions correlate with MYCN amplification, suggesting that two tumor suppressor regions exist in 1p36, a distal and proximal region, which have MYCN-independent and dependent roles. To interrogate this, we genome-edited a proximal candidate, Arid1a, a distal candidate, Chd5, and engineered a syntenic 1p36 LOH deletion in primary mouse NCCs, the likely cell of origin for NBL. Chd5 deletions were found to confer most of the pro-tumorigenic functions of 1p36 LOH in cells expressing endogenous Mycn levels. In contrast, reduced tumor latency in Mycn-driven oncogenesis significantly correlated with the loss of Arid1a. Gene expression analysis found that tumors presenting early onset display a Polycomb Repressive Complex 2 (PRC2) signature and an impaired Trp53 signaling pathway signature. Our findings delineate the tumor suppressor functions of 1p36 LOH in NBL and potentially provide critical insights for the constellation of cancers with 1p36 deletion.

2019-12-01 | GSE123281 | GEO