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MFOLFOXIRI for oligometastatic CRC

ABSTRACT: Interventions: [First step eligible patients] 1)Surgery based on the principle of each site. Second step surgery for primary tumor and metastatic tumor(s) are alllowed 2)Blood exam for cfDNA/ctDNA analysis at four points; before surgery, 28days after surgery, 4 months after surgery and 7 months after surgery [Second step eligible patients] mFOLFOXIRI therapy (8 cycles maximum) mFOLFOXIRI administered every 2 weeks for 8 cycles maximum 1. 90min infusion of irinotecan 150 mg/m2 (day1) 2. 2-hour infusion of oxaliplatin 85 mg/m2 and levofolinate 200 mg/m2(day1) 3. 48-hour continuous infusion (day2-3) [Maintenance therapy (4 cycles)] 1) 2-hour infusion of levofolinate 200 mg/m2 2) 48-hour continuous infusion of fluorouracil 2400 mg/m2;C509829;FOLFOXIRI Primary outcome(s): Treatment compliance (at 8 cycles) Study Design: single arm study, open(masking not used), uncontrolled control, single assignment, treatment purpose

DISEASE(S): Colorectal Cancer,Oigometastases Ctdna Mfolfoxiri

PROVIDER: 2615381 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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