Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Multicenter randomized control study of SO clip in colorectal ESD.

ABSTRACT: Interventions: SO clip use Primary outcome(s): procedure time Study Design: randomized controlled trial, open(masking not used), active control, parallel assignment, treatment purpose

DISEASE(S): Colorectal Tumor

PROVIDER: 2615533 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

Efficacy of complete clip closure of the mucosal defect after colorectal-ESD : A randomized controlled, multicenter trial (CCC trial)

Project description:Interventions: without clip closure after ESD complete clip closure after ESD Primary outcome(s): Delayed adverse event rates (Post-ESD coagulation syndrome, delayed bleeding, delayed perforation), intention to treat analysis Study Design: Parallel Randomized

| 2654643 | ecrin-mdr-crc

The investigation of prophylactic clip hemorrhage control for colorectal cold snare polypectomy in patients taking anti-thrombotic drugs.

Project description:Interventions: Patients who meet the inclusion criteria and do not meet the exclusion criteria are randomly assigned 1:1 to the clip closure group or the non-clip closure group. Hematochezia will be evaluated in a patient diary for 2 weeks after the cold snare polypectomy.;D016430;CSP clip Antithrombotics Primary outcome(s): Percentage of delayed bleeding within 2 weeks after CSP (per patient). Delayed bleeding is defined as hematochezia requiring endoscopic hemostasis within 2 weeks after CSP. Study Design: randomized controlled trial, open(masking not used), no treatment control/standard of care control, parallel assignment, treatment purpose

| 97511 | ecrin-mdr-crc

Camk2a-neuron specific FLAG-Ago HITS-CLIP

Project description:The HITS-CLIP procedure was used to detect miRNA mediated Argonaute (Ago) binding in Camk2a mouse neurons.

2023-01-31 | GSE211552 | GEO

TARBP2 HITS-CLIP

Project description:In order to identify TARBP2 binding sites on endogenous RNA, we performed HITS-CLIP on a myc-tagged TARBP2 expressing cell-line (transient transfection) Cells were transfected with tagged TARBP2 vector (Origene) and 48-hr post-transfection, they were subjected to the HITS-CLIP procedure (Licatalosi D, et al. 2008, Nature 456:464-U22)

2014-07-24 | E-GEOD-49648 | biostudies-arrayexpress

A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins (CLIP)

Project description:Crosslinking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins (RBPs). We developed a method for CLIP data analysis and applied it to compare 254 nm CLIP with PAR-CLIP, which involves crosslinking of photoreactive nucleotides with 365 nm UV light. We found small differences in the accuracy of these methods in identifying binding sites of HuR, a protein that binds low-complexity sequences and Argonaute 2, which has a complex binding specificity. We show that crosslink-induced mutations lead to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect sufficiently their sites under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific ribonucleases strongly biases the set of recovered binding sites. We finally show that this bias can be substantially reduced by milder nuclease digestion conditions.

2011-05-15 | GSE28859 | GEO

A multicenter prospective study of the efficacy of prophylactic clip closure for prevention of delayed bleeding after colorectal ESD (endoscopic submucosal dissection)

Project description:Interventions: Prophylactic clip closure after colorectal ESD Primary outcome(s): The rate of delayed bleeding after prophylactic clip closure Study Design: Single arm Non-randomized

| 2651772 | ecrin-mdr-crc

A randomized control trial of efficacy of endoscopic submucosal dissection using an ITknife nano for colorectal neoplasms larger than 30 mm in size

Project description:Interventions: Patients receive endoscopic submucosal dissection (ESD) for colorectal epitherial neoplasms. Primary outcome(s): Procedure time Study Design: randomized controlled trial, open(masking not used), active control, parallel assignment, treatment purpose

| 2612913 | ecrin-mdr-crc

A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins (CLIP)

2011-05-15 | E-GEOD-28859 | biostudies-arrayexpress

Nuclear HNRNPA2B1 HITS-CLIP and RNA-seq

Project description:To identify HNRNPA2B1 binding sites on endogenous nuclear RNAs, we performed HITS-CLIP for endogenous HNRNPA2B1 and RNA-seq to analyze the nuclear RNA under either METTL3 or HNRNPA2B1 depletion. Wild type MDA-MB-231 cells were subjected to the HITS-CLIP procedure on immunoprecipitated HNRNPA2B1 associated RNA obtained from the nuclear fraction (Licatalosi D, et al. 2008, Nature 456:464-U22). For RNA-seq, nuclear RNA was extracted from MDA-MB-231 or Hela cells knocked down for METTL3 or HNRNPA2B1.

2015-06-20 | E-GEOD-70061 | biostudies-arrayexpress

Canakinumab treatment for recent-onset type 1 diabeties mellitus: a multicenter randomized, placebo-controlled trial

Project description:Background: Blocking the action of the pro-inflammatory cytokine interleukin-1 (IL-1) reduces beta-cell secretory dysfunction and apoptosis in vitro, diabetes incidence in animal models of Type 1 diabetes mellitus (T1D), and glycaemia via improved beta-cell function in patients with T2D. We hypothesised that canakinumab, a monoclonal antibody to IL-1B, improves beta-cell function in patients with new-onset T1D. Methods: In an individually randomised, two-group parallel trial involving 12 sites in US, 69 patients aged 6-45 with T1D, < 12 weeks of symptoms, and assigned by centralised computer-generated blocked randomisation with locked computer-file concealment to treatment with 2 mg/kg (maximum 300 mg) canakinumab (n=45) or placebo (n=22) monthly for 12 months as add-on to conventional therapy. Participants and care-givers, but not data monitoring unit, were masked to group assignment. The primary end-point was change in the two-hour area-under-the-curve C-peptide response to MMT 12 months.

2015-10-01 | GSE68049 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data