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Study of the effect of flurbiprofen for prevention of mesenteric traction syndrome.

ABSTRACT: Interventions: Administration of flurbiprofen axetil during induction of anesthesia Administration of flurbiprofen axetil after the onset of mesenteric traction syndrome. No preventive action Primary outcome(s): The incidence of mesenteric traction syndrome Study Design: Parallel Randomized

DISEASE(S): Mesenteric Traction Syndrome (colorectal Cancer)

PROVIDER: 2624512 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Interference with PPAR gamma signaling in mesenteric artery

Project description:Pharmacological activation of the transcription factor PPAR gamma lowers blood pressure and improves glucose tolerance in humans. In contrast, naturally occurring mutations (e.g., P467L, V290M) in the ligand binding domain of PPAR gamma in humans leads to severe insulin resistance and early-onset hypertension. Experimental evidence, including whole genome expression profiling, suggests that these mutant versions of PPAR gamma act in a dominant negative manner. Because PPAR gamma is expressed in a variety of cell types and tissues, we generated a transgenic mouse model (SP467L) specifically targeting dominant negative PPAR gamma to the vascular smooth muscle cells in order to determine the action of PPAR gamma in the blood vessel independent of its systemic metabolic actions. In the data set provided herein, we examined the gene expression profile in mesenteric vessels from SP467L mice and their control littermates using the Affymetrix mouse exon 1.0 ST array. We generated transgenic mice specifically targeting expression of mutant dominant negative human PPAR gamma (P467L) to vascular smooth muscle using a smooth muscle-specific promoter (smooth muscle myosin heavy chain or SMMHC). Mesenteric arteries were isolated from 3 male transgenic mice and 4 non-transgenic littermate controls. Total RNA was prepared using conventional methods and quality was assessed using the Bioanalyzer 2100 (Agilent Technologies). For the microarray hybridizations, each sample corresponded to mesenteric artery derived from one mouse. All procedures were conducted at the University of Iowa DNA Core facility using standard Affymetrix protocols. In brief, approximately 50 ng of total RNA was used as input to a two-step amplification procedure (NuGen, http://www.nugeninc.com/) to generate biotin-labeled RNA fragments for hybridization to the Affymetrix mouse exon 1.0 ST array.

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Macrophages Mediate the Repair of Brain Vascular Rupture through Direct Physical Adhesion and Mechanical Traction

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Macrophages Mediate the Repair of Brain Vascular Rupture through Direct Physical Adhesion and Mechanical Traction

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Interference with PPAR gamma signaling in mesenteric artery

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Crnic Institute Human Trisome Project - Trisomy 21 Model Atlas: PolyA RNA-seq from adult mouse mesenteric lymph nodes

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Expression data from adult mouse mesenteric arteries

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Expression data from pig mesenteric lymph nodes

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