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A single-center retrospective study regarding the exacerbation factor for post ESD electrocoagulation syndrome (PECS) after colorectal ESD

ABSTRACT: Primary outcome(s): The exacerbation factors for PECS after colorectal ESD

DISEASE(S): Colorectal Neoplasia

PROVIDER: 2653581 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Transcription profiling by array of mouse embyronic stem cells and ESD-EpiSCs

Project description:The comparison of mouse ESCs and ESD-EpiSCs was done using three biological replicates for each cell type. ESC samples (ESR1 p10, p20, ESR1/E p15) and ESD-EpiSC samples (EpiSC-7 p20, EpiSC-5 p22, and EpiSC-7 p25) were used for microarray analysis. Total RNA was extracted using Trizol and labeled and hybridized to Agilent Whole Mouse Genome Oligo 4X44K Microarrays (one-color platform) according to the manufacturers protocols.

2010-05-12 | E-MEXP-2691 | biostudies-arrayexpress

Neuroimaging abnormalities in patients with Cowden syndrome: Retrospective single-center study.

Project description:Background:We retrospectively reviewed the neuroimaging findings of patients with Cowden syndrome and determined their frequency in a single cohort. Methods:Electronic medical records were queried from January 1999 to January 2017 to identify patients who fit the clinical criteria for diagnosis of Cowden syndrome with or without a documented PTEN mutation. Patients with brain MRI examinations were then identified. Results:We retrospectively identified 44 patients with Cowden syndrome, 22 of whom had neuroimaging for review. Eleven (50%) had Lhermitte-Duclos disease, 4 (18.1%) had meningiomas, 13 (59.1%) had at least one developmental venous anomaly, 3 had cavernous malformations, 2 had evidence of dural arteriovenous fistula, 7 had increased white matter signal abnormalities relative to age (31.8%), 4 had prominent perivascular spaces, cerebellar tonsillar ectopia was present in 7 of 21 (33.3%), and 1 had cortical malformation. Conclusions:It is important to recognize that in addition to Lhermitte-Duclos disease, other intracranial findings such as multiple venous anomalies, meningiomas, greater than expected white matter signal abnormality, prominent perivascular spaces, and cortical malformations may warrant a thorough evaluation for Cowden syndrome in the appropriate clinical setting. We further recommend that this broader spectrum of intracranial abnormalities be considered for addition to the Cowden syndrome diagnostic criteria at the time of next revision.

| S-EPMC6075984 | biostudies-literature

The efficacy and safety of Multi Loop Traction Device for colorectal ESD: a single center randomized control trial

Project description:Interventions: normal colorectal ESD colorectal ESD with MLTD Primary outcome(s): resection time (from the start of resection to the end of resection) Study Design: Parallel Randomized

| 2661025 | ecrin-mdr-crc

A single-center, retrospective analysis of genotype-phenotype correlations in children with Dravet syndrome.

Project description:PurposeDravet syndrome is an early-onset epileptic encephalopathy caused most often by loss-of-function SCN1A variants. Following recognition of its genetic basis and unique clinical features, Dravet syndrome has become one of the most well-studied genetic epilepsies. We sought to evaluate the genetic diversity and correlative seizure phenotype, comorbidities, and response to antiepileptic therapies of patients with clinically-diagnosed Dravet syndrome seen in a tertiary care center. The goal of this study was to examine genotype-phenotype correlations and to ascertain if specific antiepileptic therapies may be more effective on the basis of genetic test result alone.MethodRetrospective chart review of demographics, comorbidities, seizure types, and responses to antiepileptic therapies of all patients (n = 137) with a clinical diagnosis of Dravet syndrome seen at Lurie Children's Hospital of Chicago from 2008 to 2016.ResultsOf the 96% of Dravet syndrome patients with pathogenic SCN1A variants subdivided by missense or truncating variant, there was no difference in clinical presentation. Response to antiepileptic therapies did not differ by genotype with regard to medication class.ConclusionsThis is the largest cohort of Dravet patients from within the US to report medication response with respect to genotype. Missense variants in SCN1A were most common in the voltage-sensor and pore domains. All patients were most likely to respond to the recommended medication triad compared to other antiepileptic therapies.

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Prospective, Consecutive, Single-Center Study Western (Greek) Single-Center Experience of Endoscopic Submucosal Dissection (ESD) for Early Gastrointestinal Neoplasia. That is really possible in a Greek General Hospital.

Project description:Interventions: Endoscopic submucosal dissection (ESD) Primary outcome(s): Endoscopic ’en bloc’ and complete pathological R0 resection. Study Design: Single arm Non-randomized

| 2624630 | ecrin-mdr-crc

Integrative analysis of miRNA-mRNA expression profiles in esophageal fibrosis after ESD

Project description:Integrative analysis of miRNA-mRNA expression profiles in esophageal fibrosis after ESD

| PRJNA716320 | ENA

Gonadal DNA methylomes of half-smooth tongue sole Cynoglossus semilaevis

Project description:Environmental sex determination (ESD) occurs in divergent, phylogenetically unrelated taxa, and in some species co-occurs with genetic sex determination (GSD) mechanisms. Although epigenetic regulation in response to environmental effects has long been proposed to be associated with ESD, a systemic analysis on epigenetic regulation of ESD is still lacking. Using half-smooth tongue sole (Cynoglossus semilaevis) as a model – a marine fish which has both ZW chromosomal GSD and temperature-dependent ESD – we investigated the role of DNA methylation in transition from GSD to ESD by comparing gonadal DNA methylomes of parental females, parental pseudo-males, F1 females, F1 pseudo-males and normal males.

2014-01-23 | GSE41129 | GEO

Submucosal Fibrosis Prediction in Colorectal Tumor undergoing ESD

Project description:Primary outcome(s): Predictive factors for presence of severe submucosal fibrosis(F2) in colorectal tumor undergoing ESD

| 2644656 | ecrin-mdr-crc

Prospective, single-blind, randomized controlled trial on effectiveness of single balloon overtube for ESD performed right semicolon lesion.

Project description:Interventions: ESD with single balloon overtube ESD without single balloon overtube Primary outcome(s): treatment time Study Design: Parallel Randomized

| 2647924 | ecrin-mdr-crc

Persistent Mullerian Duct Syndrome: A Single-Center Experience.

Project description:Context:Persistent Mullerian duct syndrome (PMDS) is a rare disorder. It is a type of male pseudohermaphroditism, usually presenting as "Hernia Uteri Inguinalis". Aims:This study aims to present our experience of PMDS, over a 7-year period. Settings and Design:Our center is a tertiary care facility, situated in Tamil Nadu, a southern state of India. Subjects and Methods:This is a retrospective study. The study period was from 2007 to 2015. Seven cases presented during that period. The difficulties in diagnosis, treatment options discussed, along with a review of literature are presented. Results:Seven cases of PMDS presented over 8 years. Only four were diagnosed preoperatively. Mullerian remnants were excised in five cases. Conclusions:PMDS is rare. Orchiopexy should be the goal of treatment.

| S-EPMC6182940 | biostudies-other

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