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Closure versus non-closure pelvic peritoneum in laparoscopic abdominoperineal resection for low rectal cancer: a randomized controlled trial

ABSTRACT: Interventions: group A:Closure of pelvic floor peritoneum;group B:No closure of pelvic floor peritoneum Primary outcome(s): Intraoperative conditions: operation time, closure of the pelvic floor peritoneal suture time, intraoperative blood loss;Postoperative complications: perineal incision infection, abdominal infection, abdominal bleeding or perineal incision bleeding, radioactive enteritis, intestinal fistula, vaginal fistula, bladder fistula obstruction, recurrent intestinal obstruction requiring surgical intervention, and the incidence of perineal hernia, parastomal hernia, reoperation Study Design: Randomized parallel controlled trial

DISEASE(S): Low Colorectal Cancer

PROVIDER: 2663460 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Physical Exercise for Colorectal Cancer Patients After Transanal Total Mesorectal Excision

Project description:Fecal incontinence is common in patients with rectal cancer after surgery. Previous studies showed that pelvic floor muscle and external sphincter muscle training after stoma closure could improve the severity of incontinence and other fecal symptoms, but there is no study about the effects of pelvic floor muscle exercise intervention before stoma closure. We are wondering would the symptom of fecal incontinence recover sooner and better if we give the pelvic floor muscle exercise intervention before the stoma closure. This article aims at comparing the effects of pelvic floor muscle training before stoma closure on fecal incontinence (pre-intervention group) with pelvic floor muscle training after stoma closure (post-intervention group), and we hypothesise that the severity of fecal incontinence will improve sooner and better in pre-intervention group.

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A vagal reflex evoked by airway closure

Project description:Airway integrity must be continuously maintained throughout life. Sensory neurons guard against airway obstruction and on a moment-by-moment basis, enact vital reflexes to maintain respiratory function. Decreased lung capacity is common and life-threatening across many respiratory diseases, and lung collapse can be acutely evoked by chest wall trauma, pneumothorax, or airway compression. Here, we characterize a neuronal reflex of the vagus nerve evoked by airway closure that leads to gasping. In vivo vagal ganglion imaging revealed dedicated sensory neurons that detect airway compression but not airway stretch. Vagal neurons expressing PVALB mediate airway closure responses, and innervate clusters of lung epithelial cells called neuroepithelial bodies (NEBs). Stimulating NEBs or vagal PVALB neurons evoked gasping in the absence of airway threats, while ablating NEBs or vagal PVALB neurons eliminated gasping to airway closure. Single-cell RNA sequencing revealed that NEBs uniformly express the mechanoreceptor PIEZO2, and targeted knockout of PIEZO2 in NEBs also eliminated responses to airway closure. NEBs are dispensable for the Hering-Breuer inspiratory reflex, indicating that discrete terminal structures detect airway closure and inflation. Like Merkel cells involved in touch sensation, NEBs are PIEZO2-expressing epithelial cells, and moreover, are critical for an aspect of lung mechanosensation. These findings expand our understanding of neuronal diversity in the airways, and reveal a dedicated vagal pathway that detects airway closure to help preserve respiratory function.

2024-03-06 | GSE252735 | GEO

Evaluation of the extraction site location in laparoscopic colorectal surgery midline incision vs off midline incision Randomized controlled study

Project description:Interventions: midline incision Extend the trocar hole in the umbilicus. Closure wound is suturing the white line and the peritoneum all together, suturing closure of the skin, compressing the cotton ball into the umbilicus. off midline incision Extend the transrectus trocarshole. Closure wound closes the skin by suturing the peritoneum and the posterior sheath, suturing the rectus abdominis anterior sheath and suturing the skin. Primary outcome(s): We will evaluate the small incision in the first year after surgery using postoperative wound evaluation POSAS (patient and observer scar assessment scale). Study Design: Parallel Randomized

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Effect on Incisional Hernia of Absorbable Barbed Suture for Midline Fascial Closure in Minimally Invasive Surgery for Colorectal and Gastric Cancers: A Prospective Randomized Trial

Project description:Interventions: Medical Device : All patients enrolled this trial will have midline incision for the extraction of resected specimen. For the closure of midline incision, patients allocated in experimental group will receive continuous running suture using absorbable barbed suture material. Patients allocated in control group will receive continuous running suture using absorbable nonbarbed suture material. Primary outcome(s): incisional hernia incidence rate Primary Purpose : Prevention, Intervention Model : Parallel, Blinding/Masking : Single, Blinding Target : Subject, Outcome Accessor, Allocation : RCT

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Pelvic floor muscle response after simulated birth injury and mechanisms of a skeletal muscle-derived ECM hydrogel (SKM)

Project description:Time course of pelvic floor muscles response was investigated, together with the efficacy of an ECM hydrogel therapy.

2023-08-30 | GSE237062 | GEO

Neural tube closure defect

Project description:Neural tube closure defect

| PRJNA704672 | ENA

Impact of the non-muscle cutting periumbilical transverse incision on the risk of incisional hernia compared to the midline incision during laparoscopic colorectal cancer surgery: A randomized controlled multi-center trial

Project description:Interventions: Procedure/Surgery : Incision for removal or anastomosis of colon tissue is performed by extending the laparoscopic incision horizontally. A transverse incision is made in the anterior fascia of the rectus muscle. The abdominal rectus muscle is not incised, but the muscles are lateralized out to find the posterior fascia and peritoneum and incise horizontally. Primary outcome(s): Incisional hernia incidence rate of 1 year (12 months) from the date of surgery Primary Purpose : Other(To demonstrate that transverse incision after laparoscopic colorectal cancer surgery reduces the incidence of incisional hernia compared to vertical incision around the umbilicus), Intervention Model : Parallel, Blinding/Masking : , Blinding Target : , Allocation : RCT

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Transcriptomic analysis of the effects of long-term menopause on vaginal wall tissue in rats

Project description:Long-term menopause is considered to be one of the risk factors for pelvic organ prolapse. In the case of long-term menopause, the supporting function of the pelvic floor tissue is weakened, but the effect on the vaginal wall tissue is not fully elaborated. This study intends to use transcriptomics to further clarify.

2023-06-14 | GSE220515 | GEO

Transcriptome profiling at neural tube closure site

Project description:Maternal diabetes is a teratogen that can lead to neural tube closure defects in the offspring. We therefore sought to compare gene expression profiles at the site of neural tube closure between stage-matched embryos from normal dams, and embryos from diabetic dams. Neurulation-stage mouse embryos at 8.5 days of gestation were used to prepare neural tissue at the anterior aspect of neural tube closure site 1. Tissue was procured from the open neural tube immediately anterior of the closure site, and from the closed neural tube immediately posterior to the closure site by laser microdissection. For each sample, 10 sections were pooled, total RNA was extracted, and 7 ng of total RNA were used for expression profiling by Tag sequencing using an Applied Biosystems SolidSAGE kit for library construction, and an AB SOLiD 5500 XL instrument for sequencing. Sequence reads were mapped to RefSeq RNA, and count data per gene were obtained using a modified version of the Applied Biosystems SOLiDâ?¢ SAGEâ?¢ Analysis Software. diabetic dam - closed neural tube // diabetic dam - open neural tube // normal dam - closed neural tube // normal dam - open neural tube

2016-10-24 | E-GEOD-41876 | biostudies-arrayexpress

The effect of pelvic floor muscle training on bowel symptoms after low anterior resection for rectal cancer.

Project description:Interventions: Control group + intervention group: LARS-score, Colorectal Functional Outcome Questionnaire, International Consulation on Incontinence Questionnaire, Female Sexual Function Index/ Interternational Index of Erectile Function, Flemish Physical Activity Questionnaire, Numeric Rating Scale, Bowel Diary, Bladder Diary, 1 hour Pad test, Evaluation pelvic floor muscles (tone, strength, endurance) Intervention group: pelvic floor muscle training (9 times in 12 weeks) High Resolution Pan Colonic manometry in a subset of patients with remaining symptoms Primary outcome(s): LARS-score, evaluated after 12 weeks (=16 weeks after surgery/closure ileostomy) of pelvic floor muscle training Study Design: Randomized controlled trial, Double blinded (masking used), Active, Parallel

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