Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The multi-center clinical study of perioperative electroacupuncture on intestinal barrier to enhance recovery after colorectal cancer surgery

ABSTRACT: Interventions: Group 2:Systemic intravenous anesthesia + perioperative electropuncture;Group 1:Systemic intravenous anesthesia Primary outcome(s): anal exhaust time;D-lactose;diamine-oxidase;endotoxin Study Design: Randomized parallel controlled trial

DISEASE(S): Colon-rectal Cancer

PROVIDER: 2679319 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

Intraoperative Appliance of Dexmedetomidine During Laparoscopic Resection of Colorectal Cancer:Influence on Early Postoperative Intestinal Function and Long-term Prognosis

Project description:Interventions: Dexmedetomidine:Dexmedetomidine 1ug/kg iv.pump;Control:Same dose of NS iv.pump Primary outcome(s): Anus exhaust time;Defecating time;Time of intake;Length of hospitalization;Quality of sleep;Diamine oxidase, DAO;Intestinal fatty acid binding protein, L-FABP Study Design: Parallel

| 2664946 | ecrin-mdr-crc

Clinical study on the effect of virtual reality technology on intestinal function of patients undergoing gastrointestinal surgery during fasting

Project description:Interventions: Experimental group:Use virtual reality equipment;Control group:Routine medical care measures Primary outcome(s): Intestinal microflora diversity and community structure distribution;Diamine oxidase;Intestinal fatty acid binding protein;Time of first postoperative defecation;Time of first postoperative exhaust;Recovery time of first bowel sounds Study Design: Parallel

| 2759490 | ecrin-mdr-crc

Effect of intestinal preparation based on rapid rehabilitation surgery on intestinal barrier function in patients undergoing surgery for gynecological malignant tumors

Project description:Interventions: control group:mechanical bowel preparation before surgery;experimental group:non-mechanical bowel preparation before surgery Primary outcome(s): postoperative gastrointestinal function parameters;postoperative gastrointestinal symptoms;plasma concentrations of D-lactate;plasma concentrations of diamine oxidase Study Design: Parallel

| 39263 | ecrin-mdr-crc

Inhibition of diamine oxidase promotes uptake of putrescine from rat small intestine

Project description:Metformin, a biguanide molecule, which is used as first line therapy for type 2 diabetes. In this study, we would like to investigate the inhibition of an enzyme called diamine oxidase (DAO) (also known as ABP1), by metformin. Based on our preliminary in vitro study using diamine oxidase enzyme, we saw increased level of putrescine with increasing metformin concentrations (see reference PMID: 26335661). This proposed in vivo study was to determine whether metformin could increase putrescine levels and other metabolites in mice. Aminoguanidine, a known inhibitor of DAO, in this study as positive control, following similar study design described in this paper (PMID: 8912017).

2016-05-16 | ST000401 | MetabolomicsWorkbench

Study on intestinal microenvironment and immune function of patients with pelvic tumor radiotherapy and chemotherapy by Bifidobacterium lactis M8

Project description:Interventions: treatment group:Bifidobacterium lactis M8;Control group:None Primary outcome(s): D-lactic acid;Plasma diamine oxidase;Plasma endotoxin;Humoral immune function test;Blood routine;Macrophages;Stool routine Study Design: Randomized parallel controlled trial

| 2678393 | ecrin-mdr-crc

Transcriptomic Analysis of Rat Cerebral Cortex Reveals the Potential Mechanism of Electroacupuncture Opening Blood Brain Barrier

Project description:Therapeutic treatment options for central nervous system (CNS) diseases are greatly limited by the blood-brain barrier (BBB). Electroacupuncture (EA) can be used to induce an increase in BBB permeability on rats, providing a potential approach for the delivery of drugs from the systemic circulation into the brain. However, there remains a large gap in our knowledge regarding the impact of EA on brain gene expression. This work is focused on investigating the transcriptional changes of rat cerebral cortex following EA and expression changes in genes and bioinformatic analysis was performed. Our results provide a valuable resource that will guide mechanism research of EA opening BBB and other ways to mediate drug delivery into the brain.

2022-01-05 | GSE192885 | GEO

Astrocytes modulate a specific paraventricular thalamus-prefrontal cortex projection to enhance consciousness recovery from sevoflurane anesthesia in mice

Project description:Previous studies have proved that astrocytes may be a key neural substrate that regulates wakefulness and consciousness recovery from general anesthesia, while the exact molecular target in astrocytes is still unclear. Using virus injection and in vivo fiber photometry in mice, we found both activating astrocytes and knocking down astrocytic Kir4.1 in paraventricular thalamus (PVT) promotes the consciousness recovery from sevoflurane anesthesia. Single-cell RNA sequencing of PVT reveals two distinct cellular subtypes of glutamatergic neurons: PVTGRM and PVTChAT neurons. Patch-clamp recording results proved that Astrocytic Kir4.1-mediated modulation of sevoflurane on PVT mainly works on PVTChAT neurons. Moreover, we found that PVTChAT neurons project mainly to the mPFC. This specific paraventricular thalamus to prefrontal cortex projection is involved in recovery of consciousness from sevoflurane anesthesia indirectly through modulation of astrocytes. In summary, our findings support the novel conception that the volatile anesthetic sevoflurane can inhibit PVT astrocytic Kir 4.1 to maintain and/or increase neuronal firing of PVTChAT neurons, which mainly projects to mPFC and promotes consciousness recovery from anesthesia.

2024-07-20 | GSE240388 | GEO

Impact of anesthetics on rat hippocampus and neocortex: a comprehensive proteomic study based on label-free mass spectrometry

Project description:In this work, in vivo experiment simulating a general anesthesia and ICU sedation was designed to assess the impact of two intravenous (midazolam, dexmedetomidine) and two inhalational (isoflurane, desflurane) agents to neuronal centers for cognition (neocortex), learning, and memory (hippocampus). More than 3600 proteins were quantified across both neocortex and hippocampus. Proteomic study revealed relatively mild effects of anesthetics, nevertheless, protein dysregulation uncovered possible different effect of isoflurane (and midazolam) compared to desflurane (and dexmedetomidine) to neocortical and hippocampal proteins.

2024-05-23 | PXD045159 | Pride

Effect of preoperative acupoint electroacupuncture stimulation on postoperative recovery of patients undergoing radical colorectal cancer

Project description:Interventions: C groups:Acupoint electroacupuncture stimulation from one day to 30 minutes before operation;A group:Intravenous anesthesia;B group:Acupoint electroacupuncture stimulation one day before operation Primary outcome(s): awake score;VAS score Study Design: Parallel

| 48297 | ecrin-mdr-crc

Transcriptome Exploration in Anisodus acutangulus for Further Understanding of the Tropane Alkaloids Biosynthesis

Project description:We analyzed the transcriptome of A. acutangulus roots by deep RNA sequencing to dig TAs biosynthetic genes. KOG (Eukaryotic Orthologous Groups) and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway enrichment analyses identified 48 unigenes referring to the tropane, piperidine and pyridine alkaloid biosynthesis, 145 unigenes presumably involved in distribution of arginine to TAs biosynthesis, and 86 unigenes referring to the terpenoid backbone biosynthesis. Furthermore, 82 unigenes annotated as cytochrome P450 family members seemed to be involved in secondary metabolism pathways. Previously unknown TAs biosynthetic genes in A. acutangulus, which encode littorine mutase/monooxygenase (CYP80F1) and diamine oxidase (DAO), were identified by this study.

2016-07-08 | GSE62162 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data