Proteomics

Dataset Information

0

Impact of anesthetics on rat hippocampus and neocortex: a comprehensive proteomic study based on label-free mass spectrometry

ABSTRACT: In this work, in vivo experiment simulating a general anesthesia and ICU sedation was designed to assess the impact of two intravenous (midazolam, dexmedetomidine) and two inhalational (isoflurane, desflurane) agents to neuronal centers for cognition (neocortex), learning, and memory (hippocampus). More than 3600 proteins were quantified across both neocortex and hippocampus. Proteomic study revealed relatively mild effects of anesthetics, nevertheless, protein dysregulation uncovered possible different effect of isoflurane (and midazolam) compared to desflurane (and dexmedetomidine) to neocortical and hippocampal proteins.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Brain

SUBMITTER: Marie Vajrychová  

LAB HEAD: Marie Vajrychova

PROVIDER: PXD045159 | Pride | 2024-05-23

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
MV076_KP022_1HR_2ug_01.raw Raw
MV076_KP022_1HR_2ug_02.raw Raw
MV076_KP022_1HR_2ug_03.raw Raw
MV076_KP022_1NR_2ug_01.raw Raw
MV076_KP022_1NR_2ug_02.raw Raw
Items per page:
1 - 5 of 66
altmetric image

Publications

Impact of anesthetics on rat hippocampus and neocortex: A comprehensive proteomic study based on label-free mass spectrometry.

Astapenko David D   Vajrychova Marie M   Fabrik Ivo I   Kupcik Rudolf R   Pimkova Kristyna K   Tambor Vojtech V   Radochova Vera V   Cerny Vladimir V  

Heliyon 20240305 6

Anesthesia is regarded as an important milestone in medicine. However, the negative effect on memory and learning has been observed. In addition, the impact of anesthetics on postoperative cognitive functions is still discussed. In this work, <i>in vivo</i> experiment simulating a general anesthesia and ICU sedation was designed to assess the impact of two intravenous (midazolam, dexmedetomidine) and two inhalational (isoflurane, desflurane) agents on neuronal centers for cognition (neocortex),  ...[more]

Similar Datasets

Transcriptomics Transcription profiling of mouse brain to identify age-related transcriptional changes and the effect of dietary supplementation of vitamin E
2009-09-23 | E-GEOD-8150 | biostudies-arrayexpress
Transcriptomics A comprehensive examination of dynamic gene expression changes in the mouse brain during pregnancy and the postpartum period
2016-07-03 | E-GEOD-70732 | biostudies-arrayexpress
Transcriptomics Investigating gradients of gene expression involved in early human cortical development
2011-11-10 | E-MEXP-2700 | biostudies-arrayexpress
Transcriptomics Expression data from rat with different quantities of PS
2015-03-29 | E-GEOD-36929 | biostudies-arrayexpress
Transcriptomics Bulk RNA-seq of the human fetal neocortex, lateral ganglionic eminence and medial ganglionic eminence at 7, 9, 11 and 20 post-conceptional weeks
2021-05-13 | E-MTAB-8893 | biostudies-arrayexpress
Proteomics Human temporal neocortex brain LC-MS
2016-09-29 | PXD004499 | Pride
Transcriptomics Transcription profiling of mouse heart and brain to investigate age-related transcriptional changes and the effect of dietary supplementation of vitamin E
2008-06-16 | E-GEOD-8162 | biostudies-arrayexpress
Genomics Epigenomic Signatures of Neuronal Diversity in the Mammalian Brain
2015-06-17 | E-GEOD-63137 | biostudies-arrayexpress
Transcriptomics Transcription profiling by array of mouse neocortical neural precursor cells incubated with Wnt3a for 0,3,6 and 12 hours
2010-02-26 | E-TABM-923 | biostudies-arrayexpress
Transcriptomics Transcriptomes of germinal zones of human and mouse fetal neocortex suggest a role of extracellular matrix in progenitor self-renewal.
2012-07-02 | E-GEOD-38805 | biostudies-arrayexpress