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Preoperative Gabapentin Administration Improves Postoperative Analgesia in Patients Undergoing Laparoscopic Radical Resection of Colorectal Cancer

ABSTRACT: Interventions: two groups: gabapentin Primary outcome(s): Visual Analogue Scale/Score;Opioid consumption;nausea and vomitting Study Design: Parallel

DISEASE(S): Colorectal Cancer

PROVIDER: 2683570 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Effect of the Rational Administration on postoperative Pain and Inflammatory Reaction

Project description:Interventions: two groups:Administration according to Flurbiprofen Axetil Pharmacokinetics Primary outcome(s): visual analogue scale;bruggman comfort scale;Sufentanil Consumption;Cytokin Study Design: Randomized parallel controlled trial

| 2675110 | ecrin-mdr-crc

Effects of quaratus lumborum block versus transversus abdominis plane block on enhanced recovery after laparoscopic radical resection of colorectal cancer : A prospective randomized controlled study

Project description:Interventions: QL:Bilateral quaratus lumborum block with 0.375% ropivacaine 20ml;TAP:Bilateral transversus abdominis plane block with 0.375% ropivacaine 20ml Primary outcome(s): Visual analogue pain scale (VAS);intraoperative remifentanil consumption Study Design: Randomized parallel controlled trial

| 2675831 | ecrin-mdr-crc

Effects of quadratus lumborum block on enhanced recovery after surgery in patients following laparoscopic radical resection of colorectal cancer

Project description:Interventions: contorl:bilateral quadratus lumborum block with 0.9 normal saline (20-30ml) on each side;QLB:bilateral quadratus lumborum block with 0.33 % ropivacaine (20-30ml) on each side Primary outcome(s): sufentanil consumption;Visual analogue pain scale (VAS) Study Design: Randomized parallel controlled trial

| 2675735 | ecrin-mdr-crc

Withdraw due to duplicate registration. Dose intrathecal morphine improve postoperative analgesia in patients undergoing laparoscopic colorectal surgery?

Project description:Interventions: 0.5 mg morphine group:Patient received intrathecal 0.5 mg morphine with 15 mg ropivacaine before general anesthesia;0.25 mg morphine group:Patient received intrathecal 0.25 mg morphine with 15 mg ropivacaine before general anesthesia;Ropivacaine group:Patient received intrathecal 15 mg ropivacaine before general anesthesia Primary outcome(s): Area under the curve of activity visual simulation pain score;Postoperative cumulative consumption of opioid analgesics Study Design: Parallel

| 2760431 | ecrin-mdr-crc

Comparison of the effects of preoperative melatonin or vitamin C administration on postoperative analgesia.

Project description:The analgesic benefit of melatonin and vitamin C as primary or adjuvant agents has been reported in various studies; however, their analgesic effects in the treatment of postoperative pain remain unclear. Thus, we aimed to evaluate the effect of single preoperative dose of oral melatonin or vitamin C administration on postoperative analgesia. In this study, we recruited 165 adult patients undergoing elective major abdominal surgery under general anesthesia. Patients were randomly divided into three equal (n = 55) groups. One hour before surgery, patients received orally melatonin (6 mg) in group M, vitamin C (2 g) in group C, or a placebo tablet in group P. Pain, sedation, patient satisfaction, total morphine consumption from a patient-controlled analgesia device, supplemental analgesic requirement, and the incidence of nausea and vomiting were recorded throughout 24 h after surgery. The mean pain score and total morphine consumption were found significantly lower in both M and C groups compared with group P (p < 0.001). There were no significant differences between group M and C with respect to pain scores (p = 0.117) and total morphine consumption (p = 0.090). Patients requested less supplemental analgesic and experienced less nausea and vomiting in groups M and C compared with group P. In conclusion, preoperative oral administration of 6 mg melatonin or 2 g vitamin C led to a reduction in pain scores, total morphine consumption, supplemental analgesic requirement, and the incidence of nausea and vomiting compared with placebo.

| S-EPMC7029201 | biostudies-literature

Analgesia of naloxone and morphine in wild-type and NY1DD sickle cell mice using BMAP cDNA microarrays

Project description:Sickle cell disease is the most common genetic disorder in African-Americans. The opioid analgesic, morphine, has long been the treatment for the severe pain associated with this disease. Here we reveal that the opioid antagonist, naloxone, possesses potent analgesic activity in two strains of sickle cell mice (NY1DD and hBERK1) and not in their respective controls (ICR-CD1 and C57BL/6J) when administered by three parenteral routes. In the NY1DD sickle mice, naloxone (i.c.v.) possessed ~300-fold greater potency than morphine (i.c.v.). Other opioid antagonists (naltrexone, norbinaltorphimine, naltrindole) were substantially less effective in producing analgesia. Naloxone and morphine were synergistic in NY1DD mice, suggesting that analgesia was mediated via different receptor systems. Since microarray analysis suggested naloxone-induced down-regulation of the CCR5 chemokine receptor in NY1DD mice but not in control mice, the role of its endogenous ligand, CCL5 (RANTES), was investigated. Keywords: Comparison of drug induced gene expression

2007-12-20 | GSE6479 | GEO

Comparison of ultrasound-guided erector spinae plane block and transversus abdominis plane block in postoperative analgesia of laparoscopic colorectal cancer surgery

Project description:Interventions: TAP:Transversus abdominis plane block;ESP:Erector spinae plane block Primary outcome(s): Visual Analogue Scale Study Design: Randomized parallel controlled trial

| 2680369 | ecrin-mdr-crc

Analgesia of naloxone in wild-type and NY1DD transgenic mouse model of sickle cell anemia using BMAP cDNA microarrays

2007-03-14 | GSE6578 | GEO

The molecular basis of analgesia in congenital insensitivity to pain associated with loss of Nav1.7 function

Project description:Loss of function mutations in the SCN9a gene encoding voltage-gated sodium channel Nav1.7 cause congenital insensitivity to pain (CIP) and anosmia in otherwise normal humans and mice, suggesting that this channel may be a good analgesic drug target. Surprisingly, potent selective antagonists of Nav1.7 are weak analgesics. We therefore investigated whether Nav1.7 , as well as contributing to electrical signalling may have an additional function. Here we report that Nav1.7 deletion has profound effects on the sensory neuron transcriptome, leading to dysregulation of a number of transcription factors as well as upregulation of enkephalin precursor PENK mRNA and down regulation of CEACAM10 mRNA, a protein involved in noxious thermosensation. PENK mRNA is transcriptionally upregulated in Nav1.7 null mutant female sensory neurons, resulting in increased enkephalin expression in the dorsal horn of the spinal cord. PENK expression is down-regulated by addition of the sodium ionophore monensin, suggesting that sodium may play a role as a second messenger. Application of the opioid antagonist naloxone strongly enhances noxious peripheral input into the spinal cord, and dramatically reduces analgesia in both male and female Nav1.7 null mutant mice, as well as in human Nav1.7 null mutants. These data show that loss of Nav1.7 expression increases opioid drive over the lifetime of mice and humans. They further suggest that Nav1.7 channel blockers alone may not replicate the phenotype of null mutant humans and mice, but should be potentiated with exogenous opioids. RNA was extracted from Dorsal Root Ganglia tissue from Nav1.7 Knock-Out, Nav1.8 KO and Nav1.9 KO mice (n = 3) and hybridised on Affymetrix Mouse Genome 430 2.0 Array (GPL1261)

2014-09-13 | E-GEOD-61373 | biostudies-arrayexpress

Epidural Analgesic Therapy (EAT) versus IntraVenous patient-controlled Analgesia (IVA)

Project description:Study hypothesis: Randomised trial conducted in order to quantify the concrete validity and limitations of intravenous patient-controlled analgesia therapy (IVA) versus epidural analgesic therapy (EAT) in "Fast Track" treatment of patients submitted to video laparoscopic left hemicolectomy. Primary outcome(s): Pain control, measured with the Visual Analogue Scale (VAS) at day 0,1 and 2

| 2423879 | ecrin-mdr-crc

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