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Based on the theory of dampness toxicity of spleen deficiency and microecology, the molecular mechanism of the immune regulation of CRC by the combination of Zhengqi Liujun Cancer Suppression Decoction and Zhengqi Powder was discussed

ABSTRACT: Interventions: experimental group:Zhenqi Liujun cancer suppression soup and one plus minus zhengqi powder Primary outcome(s): Intestinal flora 16SRDNA sequencing;Peripheral blood PD-1 and PD-L1 Study Design: Single arm

DISEASE(S): Colorectal Cancer

PROVIDER: 2696130 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Gene expression in mouse liver in response to krill powder

Project description:The effect of krill powder, a mixed source of protein and n-3 PUFAs from Antarctic Krill (Euphausia superba), on hepatic gene expression was analyzed in CBA/J mice. Mice were fed a low-fat control diet or a 3% (w/w) krill powder low-fat diet for three months. Gene expression profiling on liver samples revealed that the krill powder supplemented diet modulated a large number of pathways compared to the control diet, and we focused on the genes involved in metabolic processes. Pathways involved β-oxidation, glucose metabolism, and amino acid catabolism were downregulated. In contrast, genes involved in the mitochondrial electron transport chain were upregulated. Thus, a krill powder supplemented diet had potent and specific effects on energy metabolism and oxidative phosphorylation at the gene level. This indicates that krill powder supplementation could be an approach to prevent age-related decline in mitochondrial respiratory chain function and weight loss.

2021-11-25 | GSE46049 | GEO

Powder Infant formula

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A clinical study on the Regulation of Intestinal Microenvironment in coIX Lachana Fujiang Powder for the prevention and Treatment of malignant neoplasia in advanced colorectal adenoma

Project description:Interventions: Experimental group:Yiyi Fuzi Baijiang Powder; placebo group:Yiyi Fuzi Baijiang Powder placebo Primary outcome(s): recurrence rate Study Design: Parallel

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The effect and mechanism of freeze-dried powder of Poecilobdella manillensis on improving inflammatory injury of rat glomerular mesangial cells through TXNIP / NLRP3 pathway.

Project description:In this study, transcriptome technology was used to explore the mechanism of Poecilobdella manillensis lyophilized powder to improve the inflammatory injury of rat mesangial cells.In general, this study found that TXNIP / NLRP3 signaling pathway is one of the effective mechanisms of Poecilobdella manillensis lyophilized powder to improve the inflammatory injury of diabetic nephropathy.

2024-10-09 | GSE270526 | GEO

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Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut microecology.

Project description:BackgroundThis study was to investigate the effect and its possible mechanism of fucoidan on the development of spontaneous autoimmune diabetes in non-obese diabetic (NOD) mice.Methods7-week-old NOD mice were randomly divided into three groups: control group, low-dose (300 mg/kg) and high-dose (600 mg/kg) fucoidan-treatment groups. After 5 weeks of treatment, 10 mice per group were randomly selected to be sacrificed after feces collection. The remaining 12 mice per group were fed until 26 weeks of age to assess the incidence of diabetes.ResultsTreatment with fucoidan increased serum insulin level, delayed the onset and decreased the development of diabetes in NOD mice. Fucoidan reduced the levels of strong Th1 proinflammatory cytokines, but induced Th2-bias ed. cytokine response. And dentridic cells (DCs) in fucoidan treatment group were characterized as low expression of MHC class II and CD86 molecules. TLR4 expressions and the downstream molecules in pancreas were down-regulated in fucoidan-treated groups. There were significant differences in the composition of gut flora between NOD control group and fucoidan group. Lactobacillus and Akkermansia were significantly enriched in fucoidan group.ConclusionsFucoidan could prevent the development of autoimmune diabetes in NOD mice via regulating DC/Treg induced immune tolerance, improving gut microecology, down-regulating TLR4 signaling pathway, and maintaining pancreatic internal environment.

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MS-based proteomics of soybean seeds, powder and testa

Project description:Proteomic profiling of different compartments of soybeans, including intact seeds, testa, and testa-free powder.

2020-11-06 | MSV000086419 | MassIVE

Effects of Shenlingbaizhu powder on the efficacy of chemotherapy and the quality of life of patients with ovarian cancer based on intestinal microecology

Project description:Interventions: control group:Standard chemotherapy plus Bifid Triple Viable Capsules;Experiment group:Standard chemotherapy plus Shenlingbaizhu powder;Blank group:Standard chemotherapy, no Bifid Triple Viable Capsules Primary outcome(s): Distribution of intestinal flora;Immune function test;Efficacy evaluation Study Design: Parallel

| 2706035 | ecrin-mdr-crc

The Effect of Milk Fat Globule Membrane-Containing Protein Powder on C. elegans Gene Expression

Project description:Milk-derived peptides and milk fat globule membrane (MFGM) have gained interest as health-promoting food ingredients. However, the mechanisms by which these nutraceuticals modulate the function of biological systems often remain unclear. We utilized Caenorhabditis elegans to elucidate how milk-derived Protein powders rich in MFGM, previously used in a clinical trial, affect the physiology of this model organism. Our results demonstrate that Protein powders do not affect lifespan but promote the fitness of the animals. Surprisingly, gene expression analysis revealed that Protein powders decrease the expression of genes functioning on innate immunity, which also translates into reduced survival on pathogenic bacteria. One of the innate immunity-associated genes showing reduced expression upon Protein powder supplementation is cpr-3, the homolog of human cathepsin B. Interestingly, knockdown of cpr-3 enhances fitness, but not in Protein powder-treated animals, suggesting that protein powders contribute to fitness by downregulating the expression of this gene. In summary, this research highlights the value of C. elegans in testing the biological activity of food supplements and nutraceuticals. Furthermore, this study should encourage investigations into whether milk-derived peptides and MFGM mediate their beneficial effects through the modulation of cathepsin B expression in humans.

2024-06-24 | GSE270138 | GEO

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