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Comparison of effects of desflurane and sevoflurane on postoperative cognitive dysfunction in elderly patients undergoing laparoscopic radical resection of intestinal cancer

ABSTRACT: Interventions: Group E sevoflurane:sevoflurane;Group C desflurane:desflurane Primary outcome(s): Mean arterial pressure;Heart rate;Amount of bleeding;Neuropsychological testing Study Design: Parallel

DISEASE(S): Cognitive Impairment

PROVIDER: 2703978 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Protective effect of remote ischemic preconditioning combined with sevoflurane posttreatment on myocardial injury during laparoscopic radical resection of colorectal cancer

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sevoflurane exposures on neonatal and adult mice,LC-MSMS

Project description:Sevoflurane is the most commonly used general anesthetic in pediatric surgery, but it has the potential to be neurotoxic. Previous research found that long-term or multiple sevoflurane exposures could cause cognitive deficits in newborn mice but not adult mice, whereas short-term or single inhalations had little effect on cognitive function at both ages. The mechanisms behind these effects, however, are unclear. In the current study, 6- and 60-day-old C57bl mice in the sevoflurane groups were given 3% sevoflurane plus 60% oxygen for three consecutive days, each lasting 2 hours, while those in the control group only got 60% oxygen. The cortex tissues were harvested on the 8th or 62nd day. The tandem mass tags (TMT)pro-based quantitative proteomics combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysi were applied to analyze the influences of multiple sevoflurane anesthesia on the cerebral cortex in mice with various ages. A total of 6247 proteins were measured using the combined quantitative proteomics methods of TMTpro-labeled and LC-MS/MS, 443 of which were associated to the age-dependent neurotoxic mechanism of repeated sevoflurane anesthesia. Our findings would help to further the mechanistic study of age-dependent anesthetic neurotoxicity and contribute to seek for effective protection in the developing brain under general anesthesia.

2022-12-08 | PXD037294 | Pride

To observe the effect of individualized ventilation combined with auricular acupoint pressing needle on the quality of emergence from anesthesia and postoperative cognitive function of patients undergoing laparoscopic colorectal cancer surgery o

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Next Generation Sequencing Facilitates Quantitative Analysis of sevoflurane-treated and sevoflurane-untreated U251 cells Transcriptomes

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2022-01-11 | GSE193295 | GEO

RNA sequencing of mouse after single sevoflurane exposure

Project description:we combined RNA sequencing analysis of mouse prefrontal cortex after single sevoflurane exposure

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Comparison of global gene expression profile associated with inhalation anesthesia between sevoflurane and desflurane

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2024-10-30 | GSE234493 | GEO

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Project description:We thus isolated cortex from mice, with or without sevoflurane exposure, and performed single cell sequencing. Single cell sequencing is a innovative experimental procedures which allows the identification of various subsets of cells in the neverous system after sevoflurane exposure. Isolated cells were concentrated to 1000 cells/uL and approximately 17,000 cells were loaded into each channel to generate single-cell Gel Bead-In-Emulsions (GEMs), which led to expected mRNA barcoding of 10,000 single-cells for each sample. Seurat package was used for cell normalization and regression. Sevoflurane and control groups were aligned and combined using Seurat. Using t-distributed stochastic neighbor embedding (tSNE), 13 cluters of cells were visualized. Cells were assigned to various clusters based on strong expression of specific genes.

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