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Effect of LL-TNS on postoperative intestinal function in patients with colorectal cancer

ABSTRACT: Interventions: Group A:Low frequency electrical stimulation at tragus;Group B:None Primary outcome(s): Postoperative gastrointestinal function Study Design: Parallel

DISEASE(S): Colorectal Cancer

PROVIDER: 2706135 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Effects of percutaneous electrical acupoint stimulation on the recovery of gastrointestinal function after laparoscopic colon cancer surgery

Project description:Interventions: Control group:None;TEAS group:Transcutaneous electrical acupoint stimulation (TEAS) Primary outcome(s): Serum gastrin concentration Study Design: Parallel

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Electrical stimulation of human embryonic stem cell derived cardiomyocytes

Project description:Analysis of the effect of electrical field stimulation frequency at the gene expression level. Electrical stimulation has been shown to mature nascent cardiomyocytes and alter their beating properties. The purpose of the array was to identify potential mediators of these effects. Total RNA was isolated from cardiomyocytes subjected to 0.5 Hz, 1 Hz, or 2 Hz continuous electrical stimulation for 7 days, compared to an unstimulated control. Three samples from each group were analyzed

2015-11-05 | E-GEOD-74669 | biostudies-arrayexpress

Effects of transcutaneous electrical acupoint stimulation (TEAS) on different types of pain after laparoscopic radical colorectal resection: a randomized controlled clinical trial

Project description:Interventions: TEAS group:Effect of Transcutaneous Electrical Acupoint Stimulation;Control group:None Primary outcome(s): Postoperation pain Study Design: Parallel

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Effect of transcutaneous auricular vagus nerve stimulation on postoperative gastrointestinal dysfunction in patients undergoing laparoscopic radical resection of colorectal cancer - a single-center, randomized, double-blind, controlled trial

Project description:Interventions: Test group:Stimulator treatment site placed in the ear nail boat area (set at a frequency of 25Hz, 200 µs pulse width),Each patient was treated once at 30 minutes, stimulation once a day for three days after surgery.;Control group:The electrode of the instrument was placed at the corresponding position, but no electrical stimulation was given. Primary outcome(s): The patient reported the time of first exhaust after operation Study Design: Parallel

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Electrical stimulation of human embryonic stem cell derived cardiomyocytes

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Smart-seq2 of spinal cord motoneurons in spinal cord injury model after dual electrical stimulation with specific frequencies

Project description:Electrical stimulation can augment or modify neuronal function and can have therapeutic benefits for certain neurological disorders. There is evidence that enhancing spinal excitability with either epidural or transcutaneous stimulation can restore some volitional motor output after spinal cord injury (SCI). Lumbosacral epidural stimulation temporarily improves locomotor and autonomic function in both rodents and humans with SCI. When combined with overground locomotor training enabled by a weight-supporting device, epidural electrical stimulation (EES) promotes extensive reorganization of residual neural pathways that improves locomotion after stopping stimulation. However, the exact mechanism underlying the reconstruction of spinal cord neural circuits with electrical stimulation is not yet known. Thus, we developed a epidural electrical and muscle stimulation(EEMS) system at the interface of the spinal cord and muscle to mimic feedforward and feedback electrical signals in spinal sensorimotor circuits. Using methods of motor function evaluation, neural circuit tracing and neural signal recording, we discovered a unique stimulus frequency of 10-20 Hz under EEMS conditions that was required for structural and functional reconstruction of spinal sensorimotor circuits. Single-cell transcriptome analysis of EEMS activated motoneurons characterized molecular networks involved in spinal sensorimotor circuit reconstruction. This study provides insights into neural signal decoding during spinal sensorimotor circuit reconstruction, and indicates a technological approach for the clinical treatment of SCI.

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Multidirectional effect of low-intensity electrical myostimulation on gene expression and phenotype in thigh and calf muscles after one week of disuse

Project description:Low-intensity neuromuscular electrical stimulation (NMES) is often used as an alternative to exercise and high-intensity electrical stimulation to prevent the loss of muscle mass, strength, and endurance in spaceflight and in patients with severe chronic diseases. This study assessed the efficiency of low-intensity (~10% of maximal voluntary contraction) combined (low- and high-frequency) electrical stimulation in preventing the negative effects of weekly disuse (dry immersion without [DI, see a related dataset GSE271607] and with [DI+NMES] daily stimulation; 10 males in each group) on the strength and aerobic performance of the ankle plantar flexors and knee extensors, mitochondrial function in permeabilized muscle fibers, and the proteomic (quantitative mass spectrometry-based analysis) and transcriptomic (RNA-sequencing) profiles of the soleus muscle and vastus lateralis muscle. Application of electrical stimulation during dry immersion prevented a decrease in the maximal strength and a slight reduction in aerobic performance of knee extensors, as well as a decrease in maximal ADP-stimulated mitochondrial respiration and changes in the expression of genes encoding mitochondrial, extracellular matrix, and membrane proteins in the vastus lateralis muscle. In contrast, for the ankle plantar flexors/soleus muscle, electrical stimulation had a positive effect only on maximal mitochondrial respiration, but accelerated the decline in the maximal strength and muscle fiber cross-sectional area, which appears to be associated with the activation of genes regulating the inflammatory response. The data obtained open up broad prospects for the use of low-intensity combined electrical stimulation to prevent the negative effects of disuse for “mixed” muscles, meanwhile, the optimization of the stimulation protocol is required for “slow” muscles.

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Transcription profiling by array of Arabidopsis seedlings response to three oscillating levels in cytosolic Ca2+

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2010-08-01 | E-MEXP-2663 | biostudies-arrayexpress

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Effect of hyperthermic intraperitoneal chemotherapy on intestinal flora and immune function in patients after radical distal gastrectomy for gastric cancer

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