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Construction of Dynamic Prediction Model of Low Anterior Resection Syndrome after Colorectal Cancer Surgery

ABSTRACT: Interventions: Exposed group:None;Non-exposed group:None Primary outcome(s): Comprehensive Score of Low anterior Resection Syndrome Study Design: Factorial

DISEASE(S): Colorectal Cancer

PROVIDER: 2716776 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Mass Spectrometry analysis of human matched Anterior and Posterior lobes of Pituitary

Project description:This study provides a comprehensive proteomic analysis of five matched pairs of the anterior and posterior lobe of the pituitary, which was used to study the proteomic signature specific to both anterior and posterior lobes. Anterior Lobe n=5 Posterior Lobe n=5 A441 PT441 A442 PT442 A457 PT457 A459 PT459 A460 PT460

2022-12-07 | PXD030235 | Pride

Influence of hyperthyroid conditions on gene expression in rat tibialis anterior

Project description:Extraocular muscles (EOMs) are a highly specialized type of tissue with a wide range of unique properties, including characteristic innervation, development, and structural proteins. Even though EOMs are frequently and prominently involved in thyroid-associated diseases, little is known about the immediate effects of thyroid hormone on these muscles. In order to create a comprehensive profile of changes in gene expression levels in EOMs induced by thyroid hormone, hyperthyroid conditions were simulated by treating adult Sprague-Dawley rats with intraperitoneal injections of 25 ?g T3 per 100 g body weight over the course of six weeks; subsequently, microarray analysis was used to determine changes in mRNA levels in EOMs from T3-treated animals relative to untreated controls. RNA isolated from tibialis anterior muscles of the same animals was used as a reference fast-twitch muscle. Adult Sprague-Dawley rats (initial body weight 200 ± 40 g) were fed ad libitum with standard laboratory diet and tap water. Eight rats were randomly divided into a T3-treated and a control group, three males and one female each. To simulate a chronically hyperthyroid state, T3 treatment was administered by intraperitoneal injections of 25 µg T3 (Sigma-Aldrich, St. Louis, MO, U.S.A.) per 100 g body weight. Injections were administered every second day over a period of six weeks. 24 hours after the last injection, the animals were sacrificed by CO2 asphyxiation, muscles were dissected immediately after death. Each of the four biological replicates in each group was used for a single microarray each. RNA from EOMs was used. Tibialis anterior RNA from the same animals served as a fast-twitch reference muscle.

2009-03-06 | E-GEOD-13413 | biostudies-arrayexpress

Rhodnius prolixus anterior midgut

Project description:Metagenomics analysis of Rhodnius prolixus anterior midgut

| PRJEB33861 | ENA

Proteome analyses of the human anterior temporal lobe

Project description:Characterization of the human Anterior Temporal Lobe and Corpus Callosum: C-HPP

2014-06-05 | PXD000548 | Pride

Proteome analyses of the human anterior temporal lobe

Project description:Characterization of the human Anterior Temporal Lobe and Corpus Callosum: C-HPP

2016-03-16 | MSV000079590 | MassIVE

A Hedgehog-FGF signaling axis patterns anterior mesoderm during gastrulation

Project description:Single cell technologies hold promise for resolving complex early developmental phenotypes. Here we define a novel Hedgehog (Hh)-Fibroblast Growth Factor (FGF) signaling axis for the formation of anterior mesoderm lineages during gastrulation. Single-cell transcriptome analysis of Hh-deficient mesoderm revealed selective deficits in anterior mesoderm populations—culminating in defects to anterior embryonic structures including the pharyngeal arches, heart, and anterior somites. Transcriptional profiling of Hh-deficient mesoderm during gastrulation revealed disruptions to both transcriptional patterning of the mesoderm and FGF signaling for mesoderm migration. Mesoderm-specific Fgf4/Fgf8 double mutants recapitulated anterior mesoderm defects and Hh-dependent GLI transcription factors modulated enhancers at FGF gene loci. Cellular migration defects during gastrulation induced by Hh pathway antagonism were mitigated by FGF4 protein. These findings implicate a multicomponent signaling hierarchy activated by Hh ligands from the embryonic node and executed by FGF signals in nascent mesoderm to control anterior mesoderm patterning.

2020-06-23 | GSE149335 | GEO

Systematic screening of prognostic and recurrence markers of colorectal cancer and construction of survival prediction model

Project description:Interventions: IOC group:intraoperative chemotherapy (IOC);No-IOC group:without intraoperative chemotherapy (IOC);Stricture:No;No stricture:No;Here 2 positive / RAS mutation / MSI-H / CTC positive:No;Here 2 negative / Ras wild /MSI-L / CTC negative:No Primary outcome(s): overall survival;Disease free survival Study Design: Factorial

| 2703941 | ecrin-mdr-crc

JDM microbiomes - oral - subgingival - anterior

Project description:Subgingival dental plaque (anterior) microbiomes in juvenile dermatomyositis

| PRJEB75444 | ENA

Transcription profiling of dentate gyrus and anterior cingulate cortex in mice exposed Unpredicatble Chronic Mild Stress and treated with fluoxetine

Project description:Groups of 8 adult BALB/c male mice were either untreated or exposed for 9 weeks to unpredicatble chronic mild stress (UCMS), or exposed for 7 weeks to UCMS and treated for the last 5 weeks with fluoxetine (Flx) diluted in drinking water, or untreated for 2 weeks and received Flx for 5 weeks. Total RNAs from dentate gyrus (DG) and anterior cingulate cortex (ACC) were profiled after hybridization with Agilent SurePrint G3 Mouse GE 8x60K Microarray v1 to identify transcriptional biomarkers of major depression.

2017-09-14 | GSE84183 | GEO

The recurrence risk monitoring and prediction model of colorectal cancer patients was established based on Digital Twin

Project description:Interventions: Group of colorectal cancer:None Primary outcome(s): Recurrence rates at 1, 2, 3, 4, and 5 years after surgery Study Design: Cohort study

| 113709 | ecrin-mdr-crc

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