Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Exploration and clinical validation of molecular typing of early colorectal cancer

ABSTRACT: Interventions: Case series:None Primary outcome(s): exon genes;transcriptional expression;proteome;protein phosphorylation group Study Design: Sequential

DISEASE(S): Colorectal Cancer

PROVIDER: 2739647 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

The relationship between the expression of ALDHs and the clinicopathological parameters and prognosis of patients with colorectal cancer

Project description:Interventions: Case series:None Primary outcome(s): Protein expression of each isoform of acetaldehyde dehydrogenase Study Design: Sequential

| 2716115 | ecrin-mdr-crc

Clinical validation and application of a preliminary molecular model of colorectal high-risk adenoma

Project description:Interventions: Gold Standard:Pathology examination;Index test:the preliminary molecular model of colorectal high-risk adenoma (microRNA) Primary outcome(s): MicroRNA combined expression;Sensitivity Study Design: Sequential

| 2696406 | ecrin-mdr-crc

Exon level expression profiling of colorectal cancer tissue samples (validation sample series).

Project description:Colorectal cancer is a heterogeneous disease molecularly characterized by inherent genomic instabilities, chromosome instability and microsatellite instability. In the present study we propose transcriptome instability as an analogue to genomic instability on the transcriptome level. Exon microarray data from two independent series of altoghether 160 colorectal cancer tissue samples was used for global alternative splicing detection using the FIRMA algorithm (aroma.affymetrix). The sample-wise amounts of these alternative splicing scores exceeding a defined threshold (deviating exon usage amounts) were summarized to provide the basis for description of transcriptome instability. This characteristic was shown to be associated with splicing factor expression levels and patient survival in both independent sample series.

2011-05-19 | GSE24550 | GEO

Identification of the molecular basis of anti-cancer effect of Huaier.

Project description:Intervention type:DRUG. Intervention1:Huaier, Dose form:GRANULES, Route of administration:ORAL, intended dose regimen:20 to 60/day by either bulk or split for 3 months to extended term if necessary. Control intervention1:None. Primary outcome(s): For mRNA libraries, focus on mRNA studies. Data analysis includes sequencing data processing and basic sequencing data quality control, prediction of new transcripts, differential expression analysis of genes. Gene Ontology (GO) and the KEGG pathway database are used for annotation and enrichment analysis of up-regulated genes and down-regulated genes. For small RNA libraries, data analysis includes sequencing data process and sequencing data process QC, small RNA distribution across the genome, rRNA, tRNA, alignment with snRNA and snoRNA, construction of known miRNA expression pattern, prediction New miRNA and Study of their secondary structure Based on the expression pattern of miRNA, we perform not only GO / KEGG annotation and enrichment, but also different expression analysis.. Timepoint:RNA sequencing of 240 blood samples of 80 cases and its analysis, scheduled from June 30, 2022..

| 2612481 | ecrin-mdr-crc

KNBP based MRD monitoring of resectable stage II-IV colorectal cancer and its correlation with prognosis

Project description:Interventions: Case series:None Primary outcome(s): ctDNA Study Design: Sequential

| 81452 | ecrin-mdr-crc

Study on the individualized medication of regorafenib in patients with colorectal cancer

Project description:Interventions: Case series:None Primary outcome(s): dosage Study Design: Sequential

| 2761757 | ecrin-mdr-crc

Identification of the molecular basis of anti-cancer effect of Huaier.

Project description:Intervention type:DRUG Name of intervention:Huaier Dose form / Japanese Medical Device Nomenclature:GRANULES Route of administration / Site of application:ORAL Dose per administration:20? g Dosing frequency / Frequency of use:OTHER, SPECIFY 20g? per day Planned duration of intervention:3 months to extending if necessary Intended dose regimen:20 to 60/day by either bulk or split for 3 months to extended term if necessary detailes of teratment arms:hepatocellular carcinoma, breast cancer, colorectal cancer and related gastrointestinal cancers, urologic cancers including prostate cancer, pancreas cancer, and lung cancer, etc. Comparative intervention name:None Dose form / Japanese Medical Device Nomenclature: Route of administration / Site of application: Dose per administration: Dosing frequency / Frequency of use: Planned duration of intervention: Intended dose regimen: Primary outcome(s): For mRNA libraries, focus on mRNA studies. Data analysis includes sequencing data processing and basic sequencing data quality control, prediction of new transcripts, differential expression analysis of genes. Gene Ontology (GO) and the KEGG pathway database are used for annotation and enrichment analysis of up-regulated genes and down-regulated genes. For small RNA libraries, data analysis includes sequencing data process and sequencing data process QC, small RNA distribution across the genome, rRNA, tRNA, alignment with snRNA and snoRNA, construction of known miRNA expression pattern, prediction New miRNA and Study of their secondary structure Based on the expression pattern of miRNA, we perform not only GO / KEGG annotation and enrichment, but also different expression analysis. Study Design: Comparative test, None, No, open(masking not used), EXPLORATORY

| 98681 | ecrin-mdr-crc

A prospective observational study evaluating intestinal microbiome as a biomarker to predict the efficacy and toxicity of prostate cancer patients receiveing PARP inhibitors alone or combined with novel ADT agents

Project description:Interventions: case series:None Primary outcome(s): side effects Study Design: Sequential

| 2707329 | ecrin-mdr-crc

Medical records based study for correlation between preoperative anemia and postoperative complications and prognosis in patients with colorectal cancer

Project description:Interventions: case series:None Primary outcome(s): Postoperative complications Study Design: Sequential

| 2725782 | ecrin-mdr-crc

Study on the relationship between changes of intestinal fungi and primary liver cancer

Project description:Interventions: Case series:None Primary outcome(s): intestinal fungi Study Design: Sequential

| 35158 | ecrin-mdr-crc