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PREVENT-TAKE-UP– a prevention and early detection app for integrated breast cancer, colorectal cancer, and prostate cancer screening

ABSTRACT: Interventions: Group 1: Group A comprises 10 specialists (7 general practitioners, 1 urologist, 1 gynecologist, 1 gastroenterologist), who are first interviewed by telephone in individual qualitative interviews regarding their expectations of a prevention app for the outpatient healthcare sector. After answering the questions in the app, they also evaluate the user-friendliness of the app (SUS questionnaire) and discuss its feasibility in a focus group. Group 2: Group B includes 10 preventive care-eligible individuals between the ages of 50 and 70 who are healthy with no history of breast cancer, colorectal cancer, or prostate cancer screening in the last 5 years and are interested in screening and prevention options. After answering the questions in the app on a study smartphone, group B assesses the user-friendliness of the app (SUS questionnaire) and discusses its feasibility in a focus group. Group 3: Group C includes 150 preventive care-eligible individuals between the ages of 50 and 70 who are healthy with no history of breast cancer, colorectal cancer, or prostate cancer screening in the past 5 years and are interested in screening and prevention options. After answering the questions in the app on a study smartphone, group C assesses the user-friendliness of the app (SUS questionnaire) and also evaluates the comprehensibility of the questions and the information content of the app (evaluation form). Group 4: Group D includes people interested in using the app, who are made aware of the possibility of using the app through active promotion of the app via professional societies such as the GASTRO-Liga e.V., among others, or social media channels (facebook, instagram). Group D has the opportunity to provide anonymous feedback on the app on their own smartphone after answering the Primary outcome(s): Usability: User-friendliness of the app for the prevention of tumor diseases (by means of SUS questionnaire). Feasibility: Experiences and expectations of a new communication tool as well as its comprehensibility and acceptance (via focus group discussion). Study Design: Allocation: ; Masking: ; Control: ; Assignment: ; Study design purpose: prevention

DISEASE(S): The Project Is In The Primary Prevention, A Study Of Diseases / Health Problems Does Not Take Place

PROVIDER: 2754452 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Project description:BACKGROUND AND AIMS: The increasing incidence of cardiovascular diseases has created an urgent need for safe and effective anti-thrombotic agents. Leech, as a traditional Chinese medicine, has the effect of promoting blood circulation and removing blood stasis, but its real material basis and mechanism of action for the treatment of diseases such as blood stasis and thrombosis have not been reported.METHODS: In this study, Whitmania Pigra Whitman (WPW), Hirudo nipponica Whitman (HNW) and Whitmania acranutata Whitman (WAW) were hydrolyzed by biomimetic enzymatic hydrolysis to obtain the active peptides of WPW (APP), the active peptides of HNW (APH) and the active peptides of WAW (APA), respectively. Then their structures were characterized by sykam amino acid analyzer, fourier transform infrared spectrometer (FT-IR), circular dichroism (CD) spectrometer and LC-MS. Next, the anti-thrombotic activities of APP, APH and APA were determined by carrageenan-induced tail vein thrombosis model in mice, and the anti-thrombotic mechanisms of high-dose APP group (HAPP), high-dose APH group (HAPH) and high-dose APA group (HAPA) were explored based on UHPLC-Q-Exactive Orbitrap mass spectrometry.RESULTS: The results showed that the amino acid composition of APP, APH and APA was consistent, and the proportion of each amino acid was few different. The results of FT-IR and CD showed that there were no significant differences in the proportion of secondary structures (such as β-sheet and random coil) and infrared absorption peaks between APP, APH and APA. Mass spectrometry data showed that there were 43 common peptides in APP, APH and APA, indicating that the three have common material basis. APP, APH and APA could significantly inhibit platelet aggregation, reduce black-tail length, whole blood viscosity (WBV), plasma viscosity (PV), and Fibrinogen (FIB), and prolong coagulation time, including activated partial thrombin time (APTT), prothrombin time (PT) and thrombin time (TT). In addition, 24 metabolites were identified as potential biomarkers associated with thrombosis development. Among these, 19, 23, and 20 metabolites were significantly normalized after administration of HAPP, HAPH, and HAPA in the mice, respectively. Furthermore, the intervention mechanism of HAPP, HAPH and HAPA on tail vein thrombosis mainly involved in linoleic acid metabolism, primary bile acid biosynthesis and ether lipid metabolism.CONCLUSION: Our findings suggest that APP, APH and APA can exert their anti-blood stasis and anti-thrombotic activities by interfering with disordered metabolic pathways in vivo, and there is no significant difference in their efficacies.

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PREVENT-TAKE-UP– a prevention and early detection app for integrated breast cancer, colorectal cancer, and prostate cancer screening

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