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Study on the dominant population of Quxie Capsule in different clinical pathways of metastatic colorectal cancer

ABSTRACT: Interventions: Group 1:Standard chemotherapy + Quxie Capsule;Group 2:Maintenance treatment + Quxie Capsule;Group 3:Single drug chemotherapy or targeted therapy + Quxie Capsule;Group 4:Simple TCM treatment + Quxie Capsule Primary outcome(s): Overall survival Study Design: Single arm

DISEASE(S): Colorectal Cancer

PROVIDER: 2760554 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Study on the combined scheme of Quxie Capsule in the third-line treatment of metastatic colorectal cancer and the characteristics of the dominant population

Project description:Interventions: Treatment group:Quxie capsule + Furaquitinib + Regofini + TAS-102;control group:Furaquitinib + Regofini + TAS-102 Primary outcome(s): overall survival (OS) Study Design: Non randomized control

| 41729 | ecrin-mdr-crc

Follow-up of a randomized, double-blind, controlled clinical study on reducing postoperative recurrence and metastasis of colorectal cancer with Quxie Capsule

Project description:Interventions: The treatment group:Conventional treatment add Quxie capsule;The control group:Quxie capsule was not added to conventional treatment Primary outcome(s): Survival index, 5,10,15 year survival;Factors influencing patient survival rate and disease recurrence and metastasis rate (combined disease, KPS score) Study Design: Parallel

| 2699222 | ecrin-mdr-crc

Double-blinded Randomized Controlled Trial for Qu-Xie Capsule Regulating Gut Micro-biome and Body Immune System in Patients with Advanced Colorectal Cancer

Project description:Interventions: Experimental group:Quxie capsule;Control group:Placebo Primary outcome(s): OS Study Design: Parallel

| 2690311 | ecrin-mdr-crc

Unraveling capsule biosynthesis and signaling networks in Cryptococcus neoformans

Project description:Cryptococcus neoformans is an opportunistic basidiomycete pathogen that is a major etiological agent of fungal meningoencephalitis leading to more than 180,000 deaths worldwide annually. For this pathogen, the polysaccharide capsule is a key virulence factor, which interferes with the phagocytosis by host innate immune cells, but its complex signaling networks remain elusive. In this study, we systematically analyzed capsule biosynthesis and signaling networks by using C. neoformans transcription factor (TF) and kinase mutant libraries under diverse capsule-inducing conditions, such as Dulbecco’s Modified Eagle’s (DME), Littman’s medium (LIT) and fetal bovine serum (FBS) medium. We found that deletion of GAT201, YAP1, BZP4, and ADA2 consistently causes capsule production defects in all tested media, indicating that they are capsule-regulating core TFs. Epistatic and expression analysis showed that Yap1 and Ada2 control Gat201 upstream, whereas Bzp4 and Gat201 regulate capsule production independently. We next searched for potential upstream kinases and found that mutants deleted of PKA1, BUD32, POS5, IRE1 or CDC2801 showed reduced capsule production under all three capsule induction conditions, whereas mutants deleted of HOG1 and IRK5 displayed enhanced capsule production. Notably, Pka1 and Irk5 controls induction of GAT201 and BZP4, respectively, under capsule induction condition. Finally, we monitored transcriptome profiles governed by Bzp4, Gat201, and Ada2 under capsule-inducing condition and demonstrated that these TFs regulate redundant and unique sets of downstream target genes. In conclusion, this study provides further insight into the complex regulatory mechanism of capsule production related signaling pathways in C. neoformans.

2022-10-18 | GSE208163 | GEO

Nitrogen source-dependent capsule induction in human pathogenic Cryptococcus species.

Project description:Cryptococcus neoformans causes meningoencephalitis and is an increasing human health threat. C. neoformans is neurotropic, and persists in the cerebrospinal fluid (CSF) of the mammalian host during infection. In order to survive in the host, pathogenic fungi must procure nutrients such as carbon and nitrogen. To enhance our understanding of nutrient acquisition during infection by Cryptococcus species, we examined utilization of nitrogen sources available in CSF. We screened for growth and capsule production of 817 global environmental and clinical isolates on various sources of nitrogen. Capsule production was assessed using ammonium and urea in the presence or absence of benomyl to determine the relationship of urea exposure to capsule production. Since urea is metabolized to ammonia and CO2 (a known signal for capsule induction), we examined urea metabolism mutants for their response to urea regarding capsule production. Non-preferred nitrogen sources were found to greatly affect capsule production in pathogenic species of Cryptococcus. Urea induced the greatest magnitude of capsule production. Capsule induction by urea was greater in Cryptococcus gattii strains than in C. neoformans strains. In addition, both environmental and clinical strains grew robustly on uric acid, casamino acids, creatinine, and asparagine as sole nitrogen sources. While substantial growth on nitrate was not apparent at day 3, growth was apparent by day 6 for all serotypes.

2013-09-25 | GSE46829 | GEO

Randomized Controlled Study on Effect of Quxie Capsule on the Median Survival Tim e in Patients with Advanced Colorectal Carcinoma

Project description:Interventions: treatment group:QU XIE capsule;control group:placebo Primary outcome(s): OS;PFS Study Design: Randomized parallel controlled trial

| 2665571 | ecrin-mdr-crc

Nitrogen source-dependent capsule induction in human pathogenic Cryptococcus species.

2013-09-25 | E-GEOD-46829 | biostudies-arrayexpress

Comparative genomic hybridization to study capsule switching between serogroup C and W of Neisseria meningitidis strains

Project description:Changing antigenic structure such as capsule polysaccharide is a common strategy for bacterial pathogen to evade host immune system. In this regard, the recent emergence of an invasive W:2a:P1.7-2,4 ST-11 strain in New Zealand, which is an uncommon pathogenic serogroup, was investigated for its genetic origins. Molecular typing of 103 meningococcal isolates with similar serotyping characteristics was undertaken to determine genetic relationships. Results indicated that the W:2a:P1.7-2,4 strain had emerged via capsule switching from an existing group C strain (C:2a:P1.7 2,4). Neither of the upstream and downstream sites of recombination could be elucidate but sequence analysis demonstrated that at least 45 kb of DNA was involved in the recombination event. This included the entire capsule gene cluster. Genomic DNA isolated from serogroup C strains (n=4) and serogroup W strains (n=4) were compared using Pan-neisseria DNA microarray.

2009-06-03 | E-MEXP-1910 | biostudies-arrayexpress

Expression analysis of Klebsiella pneumoniae MGH 78578 and capsule deletion mutant

Project description:To investigate the whole-genome gene expression difference between the wild-type and capsule deletion mutant in Klebsiella pneumoniae MGH 78578. The mutants analyzed in this study are further described in Huang T.W., Stapleton J.C., Chang H.Y., Tsai S.F., Palsson B.O., Charusanti P. Capsule removal via lambda-Red knockout system perturbs biofilm formation and fimbriae extression in Klesiella pneumoniae MGH 78578 (manuscript submission) A six chip study using total RNA recovered from three separate wild-type cultures and three separate cultures of a capsule deltion mutant of Klebsiella pneumoniae MGH 78578. The capsule gene cluster (KPN_02493 to KPN_02515) was entirely removed in the capsule deletion mutant. Each chip measures the expression level of 5,305 genes from Klebsiella pneumoniae MGH 78578 and the associated five plasmids (pKPN3, pKPN4, pKPN5, pKPN6 and pKPN7) with 50-mer oligo tiling array with 30-mer spacer.

2013-12-31 | E-GEOD-40011 | biostudies-arrayexpress

The effect of Bailing Capsule on gene expression in rat kidney

Project description:The effect of Bailing Capsule on gene expression in rat kidney

2022-07-01 | GSE198021 | GEO