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FOLFOX and Bevacizumab in Combination With Botensilimab and Balstilimab (3B-FOLFOX) for the Treatment of Microsatellite Stable (MSS) Metastatic Colorectal Cancer

ABSTRACT: This phase I/II trial tests the safety, side effects, best dose, and efficacy of FOLFOX and bevacizumab in combination with botensilimab and balstilimab (3B-FOLFOX) in treating patients with microsatellite stable (MSS) colorectal cancer that has spread from where it first started (primary site) to other places in the body (metastatic). Chemotherapy drugs, such as FOLFOX, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Bevacizumab is in a class of medications called antiangiogenic agents. It works by stopping the formation of blood vessels that bring oxygen and nutrients to tumor. This may slow the growth and spread of tumor. Balstilimab and botensilimab are in a class of medications called monoclonal antibodies. They bind to proteins, called PD-L1 and CTLA-4, which is found on some types of tumor cells. These PD-1 and CTLA-4 proteins are known to affect the body’s defense mechanism to identify and fight against tumor cells. The combination of these drugs may lead to improved disease control and outcomes in patients with MSS metastatic colorectal cancer.

DISEASE(S): Metastatic Colorectal Adenocarcinoma,Adenocarcinoma,Stage Iv Colorectal Cancer Ajcc V8,Stage Iv Colon Cancer Ajcc V8,Stage Iv Rectal Cancer Ajcc V8,Colorectal Neoplasms,Metastatic Microsatellite Stable Colorectal Carcinoma,Metastatic Rectal Adenocarcinoma,Colonic Neoplasms,Metastatic Colon Adenocarcinoma

PROVIDER: 2762113 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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