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Application and clinical trial of luminal nanosheets in colorectal cancer

ABSTRACT: Interventions: LDH/EDTA:Colorectal perfusion Primary outcome(s): Fecal occult blood test;Blood RT;Liver function and renal function;Tumor markers detection Study Design: Single arm

DISEASE(S): Colorectal Cancer

PROVIDER: 40615 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Leukocyte accumulation in graft blood vessels during self-limiting acute rejection of rat kidneys Immunobiology

Project description:Acute rejection episodes trigger chronic renal allograft vasculopathy. Numerous leukocytes, predominantly monocytes, accumulate in graft blood vessels during reversible acute rejection preceding chronic rejection of rat kidneys. We speculate that they contribute to transplant vasculopathy and set out to characterize them. Allogeneic renal transplantation was performed in the Fischer 344 to Lewis rat strain combination, Lewis isografts served as controls. Leukocytes were harvested by intensive perfusion of graft blood vessels and subjected to flow cytometry, quantitative RT-PCR and genome-wide transcriptional profiling.

2010-09-24 | GSE18266 | GEO

Clinical research and the mechanism of Cinobufotalin combination chemotherapy prevent the relapse and metastasis of colorectal cancer

Project description:Interventions: Trial group :Cinobufotalin combination chemotherapy ;Control:Chemotherapy Primary outcome(s): routine blood test;Urine routine test;Fecal routine test;Fecal occult blood;Liver and kidney function;Immune functionCD3?CD4;Tumor markers CA199, CEA, CA50, CA125;TCM Syndrome Rating Scale;Piper Fatigue Scale Study Design: Randomized parallel controlled trial

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Leukocyte accumulation in graft blood vessels during self-limiting acute rejection of rat kidneys Immunobiology

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Metabolomics Workbench ST000342 - GNPS - Renal metabolic pathways indicating ischemic or inflammatory changes

Project description:Tissues were acquired from kidkeys that were deemed unsuitable for transplant and were then analyzed by the lab through normothermic machine perfusion. They were perfused with either whole blood perfusate or with packed red blood cell perfusate. These tissues' metabolic pathways were then analyzed for markers of ischemic or inflammatory responses in the renal tissue

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Mechanisms and treatment of cold-storage-induced microvascular obstructions in normothermic machine perfusion of human kidney

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human gut metagenome

Project description:Microbiome analysis complements fecal occult blood test for improved detection

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First approach on the use of samples from fecal occult blood screening kits for metabolomic analysis. Application in colorectal cancer population.

Project description:Cancer is the most common disease around the world and colorectal cancer is the second most common cancer. The early diagnosis of colorectal cancer is difficult and relies on invasive diag-nostic tools such as colonoscopy and tissue biopsy. Other non-invasive techniques such as fecal occult blood screening test (FOBT) are less sensitive and accurate. The advantage of FOBT together with high throughput technology such as metabolomics could provide the advantages of non-invasive tool and the effectiveness of detecting novel colorectal cancer markers. In this way, this work focuses on the novelty of using FOBT as samples to perform metabolomics analysis and its application on colorectal cancer population.

2022-12-09 | ST002468 | MetabolomicsWorkbench

Renal metabolic pathways indicating ischemic or inflammatory changes

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Single nuclei sequencing to understand mechanism of action of the melanocortin 1 receptor agonist Pl8177 in Dextran sodium sulfate (DSS)-induced colitis in rats

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2023-01-24 | GSE223564 | GEO

Stromal netrin-1 coordinates renal arteriogenesis and mural cell differentiation

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