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The COPPER Trial: Comparision of a tumour marker in patients with appendix or right sided colon cancer

ABSTRACT: Interventions: The only intervention will be to take five ml of blood will be taken from a vein in the patient’s arm (this will be from a intravenous cannula as part of the patient’s general anaesthetic such that there will be no additional venepuncture burden) as well as another 5 ml of blood from the ileocolic / appendicular vein (a blood vessel that drains blood from the appendix or right colon that is located in the right lower side of the abdomen) during the initial stages of your peritonectomy surgery (total number of blood tests: 2; total volume: 10ml; NB: 5-10mL is equivalent to 1-2 teaspoons). The blood sampling would take less than one minute during surgery by the anaesthetist (peripheral sample) and the surgeon (portal vein sample). Assessment of the fidelity of this intervention will be in part by testing for albumin of these specimens for comparison. Primary outcome(s): Carcinoembryonic antigen (CEA) levels determined from the portal vein[Blood samples to be collected during surgery];Carcinoembryonic antigen (CEA) levels determined from the peripheral vein[Blood samples to be collected during surgery];Albumin levels determined from the peripheral and portal vein as a composite primary outcome for correlation..[Blood samples to be collected during surgery] Study Design: Purpose: Prevention; Allocation: Non-randomised trial; Masking: Open (masking not used);Assignment: Parallel;Type of endpoint: Efficacy

DISEASE(S): Colon Cancer,Appendiceal Cancer,Cancer-bowel-back Passage (rectum) Or Large Bowel (colon),Cancer-other Cancer Types,Blood-other Blood Disorders

PROVIDER: 55895 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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